Synthesis of the Antifungal Agent Neoenactin A and Its N-Deshydroxy Derivative
The first total and unequivocal syntheses of neoenactin A (1, NE A) as well as its N-deshydroxy analog 2 are described.The two key steps in the syntheses were the oxidative cleavage of an appropriate olefin 8a to yield the desired keto acid 9 and the Mich