Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists
The structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. A docking model of potent antagonist 2 with the sensor region of TRPV1 is proposed.
Lee, Jeewoo,Jin, Mi-Kyoung,Kang, Sang-Uk,Su, Yeon Kim,Lee, Jiyoun,Shin, Myoungyoup,Hwang, Jaemin,Cho, Sookhyun,Choi, Yeon-Sil,Choi, Hyun-Kyung,Kim, Sung-Eun,Suh, Young-Ger,Lee, Yong-Sil,Kim, Young-Ho,Ha, Hee-Jin,Toth, Attila,Pearce, Larry V.,Tran, Richard,Szabo, Tamas,Welter, Jacqueline D.,Lundberg, Daniel J.,Wang, Yun,Lazar, Jozsef,Pavlyukovets, Vladimir A.,Morgan, Matthew A.,Blumberg, Peter M.
p. 4143 - 4150
(2007/10/03)
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