Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases
3-Benzimidazol-2-yl-1H-indazole analogs were developed as inhibitors of receptor tyrosine kinases (RTK). The synthesis and SAR of this series is reported.
McBride, Christopher M.,Renhowe, Paul A.,Heise, Carla,Jansen, Johanna M.,Lapointe, Gena,Ma, Sylvia,Pineda, Ramon,Vora, Jayesh,Wiesmann, Marion,Shafer, Cynthia M.
p. 3595 - 3599
(2007/10/03)
3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors
The 3-benzimidazol-2-yl-1H-indazole scaffold was developed as an alternate scaffold for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, it was discovered that a subset of these compounds potently inhibit the enzy
McBride, Christopher M.,Renhowe, Paul A.,Gesner, Thomas G.,Jansen, Johanna M.,Lin, Julie,Ma, Sylvia,Zhou, Yasheen,Shafer, Cynthia M.
p. 3789 - 3792
(2008/12/23)
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