883230-94-2

Basic information

• Product Name: 5-BROMO-2-PYRAZOL-1-YL-PYRIMIDINE
• Synonyms: 5-BROMO-2-PYRAZOL-1-YL-PYRIMIDINE;5-Bromo-2-(1H-pyrazol-1-yl)pyrimidine
• CAS NO: 883230-94-2
• Molecular Formula: C7H5BrN4
• Molecular Weight: 225.0454
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 883230-94-2.mol

Chemical Properties

• Boiling Point: 402.2 °C at 760 mmHg
• Flash Point: 197 °C
• Appearance: /
• Density: 1.79g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-BROMO-2-PYRAZOL-1-YL-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-PYRAZOL-1-YL-PYRIMIDINE(883230-94-2)
• EPA Substance Registry System: 5-BROMO-2-PYRAZOL-1-YL-PYRIMIDINE(883230-94-2)

Safety Data

• Hazardous Substances Data: 883230-94-2(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-Bromo-2-pyrazol-1-yl-pyrimidine is used as a building block for the synthesis of various biologically active molecules, contributing to the development of new pharmaceutical drugs.
Used in Anticancer Research:
In the field of oncology, 5-Bromo-2-pyrazol-1-yl-pyrimidine is used as a potential anticancer agent, being studied for its ability to target and combat cancer cells.
Used in Antiviral Research:
5-Bromo-2-pyrazol-1-yl-pyrimidine is utilized in antiviral research, exploring its potential to inhibit viral replication and activity, offering a new avenue for treating viral infections.
Used in the Development of New Materials:
5-Bromo-2-pyrazol-1-yl-pyrimidine is employed in the creation and study of new materials, potentially enhancing properties such as stability, reactivity, or selectivity in various applications.
Used in Chemical Process Development:
5-Bromo-2-pyrazol-1-yl-pyrimidine is used in the innovation of chemical processes, possibly improving the efficiency, selectivity, or sustainability of industrial chemical reactions.

Upstream product

• 288-13-1 NH-pyrazole 
• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 883230-69-1 1-(5-bromopyrimidin-2-yl)-1H-benzo[d]imidazole 
• 883230-68-0 5-bromo-2-(1H-imidazol-1-yl)pyrimidine 
• 478258-70-7 5-bromo-2-(1H-pyrrol-1-yl)pyrimidine 

Relevant articles and documents

Pyrimidine-pyrazole metal ruthenium complex with catalysis property and preparation method of complex

The invention discloses a pyrimidine-pyrazole metal ruthenium complex with a catalysis property and a preparation method of the complex and relates to synthesis and an application of a transition metal complex. A molecular formula of the pyrimidine-pyrazo

Copper-Catalyzed C-N Bond Exchange of N-Heterocyclic Substituents around Pyridine and Pyrimidine Cores

A copper-catalyzed transfer N-heteroarylation strategy using a C-N bond exchange reaction is described. This reaction accommodates a wide range of pyridine and pyrimidine rings bearing halogen atoms, which have wide utility for subsequent transformations. This method provides a direct and operationally simple approach for modifying complex molecules by the exchange of N-heterocyclic substituents.

Metal-free site-selective C-N bond-forming reaction of polyhalogenated pyridines and pyrimidines

This paper presents a metal-free method for highly site-selective C-N bond-forming reaction of polyhalogenated pyridines and pyrimidines. The preferred coupling site can be tuned from the fluorine group bearing the N-heterocyclic ring to the chlorine group when changing from the pyridine ring to the pyrimidine ring. A wide array of halogenated pyridines preferentially reacted with amines at the fluorine group of the pyridine ring to generate monosubstituted halogenated pyridines with high selectivities. Different halogen atoms at various positions were produced by the pyridine ring that performed well under mild conditions. Halogenated pyrimidines underwent highly selective coupling at the chloride group with a wide range of amines having broad substrate applicability and moderate to good yields. The selectivity of the polyfluoropyridines in the developed reaction system was also tested, and the result indicated that the reaction occurred site-selectively at the ortho-position of the nitrogen ring. This reaction accommodated a wide range of halogenated groups. Thus, a wide range of chloro-, bromo-, iodo-, and fluoropyridines were generated, which have a wide utility for organic synthesis.

NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF

The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.

OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS

The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.