α-Haloalkyl Ethers in Alkylations of 2-Pyrimidinones
The ambident 5-halopyrimidin-2-one anion with potassium as counterion in DMF is preferentially O-alkylated using the relatively hard α-chloroalkyl ether electrophiles.As ammonium salts in dichloromethane or by the use of KF-alumina in DME the preference is for N-alkylation.TMS ethers of the pyrimidinones are exclusively N-alkylated.
Benneche, Tore,Undheim, Kjell
p. 345 - 350
(2007/10/02)
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