883531-07-5

Basic information

• Product Name: (5-FLUORO-1H-INDOL-2-YL)METHANAMINE
• Synonyms: (5-FLUORO-1H-INDOL-2-YL)METHANAMINE;[(5-FLUORO-1H-INDOL-2-YL)METHYL]AMINE;(5-Fluoro-1H-indol-2-yl)metanamine;1-(5-fluoro-1H-indol-2-yl)methanamine(SALTDATA: 1.08CH3SO3H);1-(5-fluoro-1H-indol-2-yl)methanamine
• CAS NO: 883531-07-5
• Molecular Formula: C₉H₉FN₂
• Molecular Weight: 164.18
• Mol File: 883531-07-5.mol

Chemical Properties

• Boiling Point: 339.073°C at 760 mmHg
• Flash Point: 158.866°C
• Appearance: /
• Density: 1.302g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: (5-FLUORO-1H-INDOL-2-YL)METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-FLUORO-1H-INDOL-2-YL)METHANAMINE(883531-07-5)
• EPA Substance Registry System: (5-FLUORO-1H-INDOL-2-YL)METHANAMINE(883531-07-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 883531-07-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(5-FLUORO-1H-INDOL-2-YL)METHANAMINE is used as a building block in organic synthesis for the development of pharmaceutical compounds due to its unique chemical structure and properties.
Used in Antitumor Applications:
(5-FLUORO-1H-INDOL-2-YL)METHANAMINE is used as a potential antitumor agent, with its therapeutic applications being studied for its effects on various types of cancer.
Used in Synthesis of Biologically Active Molecules:
(5-FLUORO-1H-INDOL-2-YL)METHANAMINE is used as a precursor in the synthesis of various biologically active molecules, contributing to the discovery of new therapeutic agents and advancements in medicinal chemistry.

InChI:InChI=1/C9H9FN2/c10-7-1-2-9-6(3-7)4-8(5-11)12-9/h1-4,12H,5,11H2

Upstream product

• 399-76-8 5-fluoroindole-2-carboxylic acid 
• 462068-77-5 5-fluoro-1H-indole-2-carboxamide 

Downstream Products

• 1449135-10-7 C₁₈H₁₄ClFN₂O₂ 
• 1449135-24-3 N-((1-acetyl-5-fluoro-1H-indol-2-yl)methyl)benzamide 
• 1426678-81-0 N-((6-methoxy-1H-indol-2-yl)methyl)-4-methyl-N-(quinolin-2-ylmethyl)benzenesulfonamide 
• 1426679-06-2 7-methoxy-2-tosyl-1,2,3,3',4',9-hexahydro-1'H-spiro[pyrido[3,4-b]indole-4,2'-quinoline] 

Relevant articles and documents

INHIBITOR OF INDOLEAMINE 2,3-DIOXYGENASE-1 AND METHODS OF MANUFACTURE AND USE THEREOF

Inhibition of indoleamine 2,3-dioxygenase (IDOl) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthriti

Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold

Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other disorders including Alzheimer's disease and arthritis. Herein, we report the structure-based design of two related series of molecules: N1-substituted 5-indoleimidazoles and N1-substituted 5-phenylimidazoles. The latter (and more potent) series was accessed through an unexpected rearrangement of an imine intermediate during a Van Leusen imidazole synthesis reaction. Evidence for the binding modes for both inhibitor series is supported by computational and structure-activity relationship studies.