883568-17-0

Basic information

• Product Name: FMOC-DL-2,4-DIMETHYLPHENYLALANINE
• Synonyms: FMOC-DL-2,4-DIMETHYLPHENYLALANINE;FMoc-2,4-diMethyl-DL-phenylalanine;Fmoc-2,4-Dimethy-DL-Phenylalanine
• CAS NO: 883568-17-0
• Molecular Formula: C₂₆H₂₅NO₄
• Molecular Weight: 415.48
• Mol File: 883568-17-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: FMOC-DL-2,4-DIMETHYLPHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-DL-2,4-DIMETHYLPHENYLALANINE(883568-17-0)
• EPA Substance Registry System: FMOC-DL-2,4-DIMETHYLPHENYLALANINE(883568-17-0)

Safety Data

• Hazardous Substances Data: 883568-17-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
FMOC-DL-2,4-DIMETHYLPHENYLALANINE is used as a building block in peptide synthesis for the development of novel pharmaceutical compounds. Its FMOC protective group allows for controlled deprotection and functionalization, facilitating the synthesis of complex peptide sequences that can be used in the creation of new drugs.
Used in Research and Development:
In the research and development sector, FMOC-DL-2,4-DIMETHYLPHENYLALANINE is utilized for the synthesis of complex peptides. Its ease of deprotection and functionalization makes it an ideal candidate for the development of new peptide-based therapeutics and for studying the properties and interactions of novel peptide sequences.
Used in Organic Chemistry:
FMOC-DL-2,4-DIMETHYLPHENYLALANINE is also used in organic chemistry for the synthesis of various organic compounds. Its unique structure and the presence of the FMOC protective group make it a versatile building block for the creation of a wide range of organic molecules with potential applications in various fields.

Upstream product

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Relevant articles and documents

Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors

Fifteen analogues of the C-terminal CA1A2X motif were synthesized and evaluated for their inhibition potency against farnesyltransferase (FTase). Replacement of the A2 residue by phenylalanine or tyrosine-derived analogues, in which a different number of methyl groups were introduced on the aromatic ring, resulted in compounds less active than the reference compound CVFM against FTase except for compounds I and VI (IC50 = 1 μM and 2.5 μM, respectively) that were comparable to CVFM and compound IV (IC50 = 0.1 μM), which was 6-fold more active than the reference compound. Because pseudopeptidic derivatives I-IX were inactive in the cellular assays, the N-formyl- and methyl-ester derivatives (compounds X-XV) were synthesized and tested on different cell lines, showing, in some cases, activity and appreciable selectivity against transformed cells. To rationalize the obtained results, molecular modeling experiments were carried out suggesting the molecular basis of FTase inhibition by these products.