Thioether-based 2-aminobenzamide derivatives: Novel HDAC inhibitors with potent in vitro and in vivo antitumor activity
Previously, we focused on a series of 2-aminobenzamide-based histone deacetylase (HDAC) inhibitors, compound 9 of which displayed potent HDAC inhibitory activity against HDAC1 and HDAC2, and moderate anti-proliferative activity against several cancer cell
ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.
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Page/Page column 59
(2008/06/13)
Kinetics of the reaction of sodium arylthiolates with nitro-carboxybenzyl halide derivatives
The rate constants for the reactions of 4-halomethyl-3-nitrobenzoic acids, the nonnitro derivatives, and their ethyl esters with arylthiolates were measured at different temperatures. It was found that the retardation in rate constants compared to benzyl halides is due to the electrostatic repulsion between the electronegative substituents (COO- and/or NO2) in the substrates and thiolate ions Good correlations between log K2 values of the acids and carbon basicities of thiolates were found while log k2 values of the esters show good straight lines with Hammett a constants, pKa. and carbon basicities of arylthiolates.
Hamed, Ezzat A.,El-Bardan, Ali A.,El-Mallah, Nabila M.
p. 283 - 289
(2007/10/03)
Synthesis and Spectral Studies of Some New Sulfides, Sulfoxides, and Sulfones. 2
New substituted benzylphenyl sulfides, sulfoxides, and sulfones have been synthesized.Their structures were confirmed by IR, (1)H NMR, and mass spectra.
Kassem, Ahmed A.,El-Bardan, Ali A.,Mansour, El-Sayed M. E.
p. 483 - 485
(2007/10/02)
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