883874-86-0

Basic information

• Product Name: 2-CHLORO-4-(4-CHLOROPHENYL)PYRIDINE
• Synonyms: 2-CHLORO-4-(4-CHLOROPHENYL)PYRIDINE
• CAS NO: 883874-86-0
• Molecular Formula: C11H7Cl2N
• Molecular Weight: 0
• Mol File: 883874-86-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-4-(4-CHLOROPHENYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-(4-CHLOROPHENYL)PYRIDINE(883874-86-0)
• EPA Substance Registry System: 2-CHLORO-4-(4-CHLOROPHENYL)PYRIDINE(883874-86-0)

Safety Data

• Hazardous Substances Data: 883874-86-0(Hazardous Substances Data)

Upstream product

• 26452-80-2 2,4-dichloropyridine 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 51791-30-1 (2E)-3-(4-chlorophenyl)but-2-enenitrile 
• 153034-86-7 2-chloro-4-iodopyridine 
• 21700-74-3 (p-chlorophenyl)triethoxysilane 

Relevant articles and documents

Preparation method of 4-aryl-2-halopyridine derivatives

4 -aryl -2 - halopyridine derivatives are disclosed. A process for preparing γ - enamine of α-unsaturated nitrile (single-activated) using a halogen source is provided to obtain high yield and efficiency under mild conditions by using 4 - a conventional double activated (double-activated -2 -) substrate through intramolecular cyclization using a halogen source.

Palladium-catalyzed c-4 selective coupling of 2,4-dichloropyridines and synthesis of pyridine-based dyes for live-cell imaging

An alternative process of Pd-catalyzed C-4 selective coupling of 2,4-dichloropyridines with boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in moderate to good yields. After further arylation, 21 examples of C-2, C-4 diarylated pyridines with a significant photophysical property were obtained, which were applied as pyridine-based dyes into live-cell imaging with good biocompatibility and low toxicity.

γ-Functionalization of α,β-Unsaturated Nitrile in Mild Condition: Versatile Synthesis of 4-Aryl-2-Bromopyridines

This report describes the synthesis of 4-aryl-2-halopyridines via γ-functionalization of α,β-unsaturated nitriles, which were obtained by the HWE reaction with the corresponding ketones. The key features of our methods involve a conjugated γ-enamine formation of α,β-unsaturated nitrile (enamino nitrile), followed by consecutive intramolecular cyclization, resulting in heteroaromatic compounds like 2-halopyridines, α-pyrone, etc.

Copper-catalyzed Hiyama coupling of (hetero)aryltriethoxysilanes with (hetero)aryl iodides

A CuI-catalyzed Hiyama coupling was achieved, which proceeds in the absence of an ancillary ligand for aryl-heteroaryl and heteroaryl-heteroaryl couplings. A P,N-ligand is required to obtain the best product yields for aryl-aryl couplings. In addition to facilitating transmetalation, CsF is also found to function as a stabilizer of the [CuAr] species, potentially generated as an intermediate after transmetalation of aryltriethoxysilanes with Cu I-catalysts in the absence of ancillary ligands.

Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents

The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.