- Synthesis method of 1-methyl-5-hydroxy pyrazole
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The invention relates to a synthesis method of 1-methyl-5-hydroxy pyrazole, which comprises the following steps of dropwisely adding tetrahydropyrrole into diethyl ethoxymethylene malonate at room temperature, and reacting at 15-80 DEG C for 2-6 hours to obtain a reaction solution A containing a compound represented by a formula (II), dropwise adding a methylhydrazine aqueous solution into the reaction solution A, and reacting at 15-80 DEG C for 2-6 hours to obtain a reaction solution B containing a compound shown as a formula (III), dropwise adding an acidic solution into the reaction solution B, and heating and refluxing for 4-8 hours at 90-120 DEG C after dropwise adding to obtain a reaction solution C containing a compound shown as a formula (IV), and carrying out post-treatment on thereaction solution C to obtain the target compound 1-methyl-5-hydroxy pyrazole. The synthesis method has the advantages of higher activity, higher reaction rate, better selectivity, higher total yield, cheap and accessible raw materials and simple post-treatment, and can obtain the solid 1-methyl-5-hydroxy pyrazole with higher purity.
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Paragraph 0014; 0030-0046
(2021/03/13)
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- An unusual thionyl chloride-promoted c?c bond formation to obtain 4,4'-bipyrazolones
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Dialkyl 5,5'-dioxo-4,4'-bipyrazole-4,4'-dicarboxylates are readily obtained by the reaction of 5-hydroxypyrazole-4-carboxylates in refluxing thionyl chloride. The obtained diesters can be transformed into the corresponding 4,4'-bipyrazoles via alkaline hy
- Eller, Gernot A.,Vilkauskaite, Gyt?,Sa?kus, Algirdas,Martynaitis, Vytas,Mamuye, Ashenafi Damtew,Pace, Vittorio,Holzer, Wolfgang
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supporting information
p. 1287 - 1292
(2018/06/13)
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- Pyrazole ketone compound or its salt, preparation method thereof, and use of the herbicide composition (by machine translation)
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This application pertains to the field of agricultural chemicals, in particular to a pyrazole ketone compound or its salt, preparation method, herbicidal composition and use. The ketone compounds states the pyrazole shown as formula I: In the formula, R 1 R 2 N representative containing substituted or unsubstituted 1-3 of the aza-3-8-membered nitrogen-containing heterocyclic base; or R 1, R 2 respectively represents hydrogen, C 1-8 alkyl etc.; R 3 representative hydrogen, C 1-4 alkyl, alkenyl, alkynyl, or unsubstituted C 1-4 alkyl substituted C 3-6 cycloalkyl; R 4 represents methyl, ethyl, n-propyl, isopropyl, cyclopropyl; X represents hydrogen, -S (O) n R 6, -R 7, containing substituted or unsubstituted 1-4 of the aza-3-8-membered heterocyclic group, wherein n representative 1, 2, 3, R 6 represents a substituted or unsubstituted alkyl or aryl, R 7 represents a substituted or unsubstituted alkyl, aryl, alkanoyl or sweet-smelling acyl. The present invention provides good efficacy of the pharmaceutical actives, easy to use, low cost, has good commercial value. (by machine translation)
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Paragraph 0063; 0064
(2016/10/08)
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- HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON 11- -HYDROXYSTEROID DEHYDROGENASE TYPE I
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Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted alkyl or the like, one of R2 and R4 is a group of formula: -Y-R5, wherein Y is -O- or the like, R5 is substituted alkyl (the substituent is optionally substituted cycloalkyl or the like), optionally substituted branched alkyl or the like, the other of R2and R4 is hydrogen or optionally substituted alkyl, R3 is a group of formula: -C(=O)-Z-R6, wherein Z is -NR7- or -NR7-W-, R6 is optionally substituted cycloalkyl or the like, R7 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, X is =N- or the like, with the proviso that compounds wherein R2 is 2-(morphorino)ethoxy, R3 is N-(1-adamantyl)carbamoyl and R1 is benzyl are excluded.
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Page/Page column 20
(2008/12/07)
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- PHOTOCHEMICAL SYNTHESIS OF 4-ETHOXYCARBONYL-5-HYDROXYPYRAZOLES
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The photochemical decomposition of 4-ethoxycarbonyl-5-diazopyrazoles in tetrafluoroboric acid results in corresponding 4-ethoxycarbonyl-5-hydroxypyrazoles (V-VII).The irradiation of the diazocompound in dioxane, toluene or tetrahydrofurane proceeds with a reductive decomposition producing corresponding 4-ethoxycarbonylpyrazole (VIII) as the main photoproduct.
- Spassova, Maria K.,Zakharieva, Rossitza D.
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p. 196 - 199
(2007/10/02)
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