cas 884500-82-7, 4H-Pyrano[2,3-b]pyridin-4-one, 2-(4-methoxyphenyl)- | Articles data ｜lookchem

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884500-82-7

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TREATMENT OF DISEASES BY EPIGENETIC REGULATION
The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of cancer as well as sepsis
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(2013/11/05)

Transition-metal-free intramolecular Ullmann-type O-arylation: Synthesis of chromone derivatives
(Chemical Equation Presented) Expect the upexpected: A transition-metal- free approach to access chromone derivatives has been developed. The intramolecular O-arylation of substituted 1-(2-haloaryl)-propane-1,3-diones in DMF in the presence of K2CO3 gave the corresponding target products in good to excellent yields (see scheme; DMF = N,N′- dimethylformamide).
Zhao, Jie,Zhao, Yufen,Fu, Hua
supporting information; experimental part
p. 3769 - 3773
(2011/05/15)

PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF COMPLEX DISEASES AND THEIR DELIVERY BY INSERTABLE MEDICAL DEVICES
The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.
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Page/Page column 57

(2008/06/13)

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Chemical Properties

Boiling Point: 425.278°C at 760 mmHg
Flash Point:211.001°C
Density: 1.289g/cm³
Vapor Pressure: 0mmHg at 25°C
PSA: 52.33000
LogP: 2.86360

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