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CAS

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885223-59-6

5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine is a chemical compound with a molecular formula C10H8N6S. It belongs to the group of thiadiazole derivatives and contains an indazole ring and a thiadiazole ring. 5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine may have potential applications in medicinal chemistry and drug discovery due to its structural features and functional groups, which could be utilized for the development of new pharmaceutical agents.

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  • 885223-59-6 Structure

  • Basic information

    1. Product Name: 5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine
    2. Synonyms: 1,3,4-Thiadiazol-2-amine, 5-(3-methyl-1H-indazol-5-yl)-; 5-(3-Methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine
    3. CAS NO:885223-59-6
    4. Molecular Formula: C10H9N5S
    5. Molecular Weight: 231.277
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 885223-59-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 524.649°C at 760 mmHg
    3. Flash Point: 271.098°C
    4. Appearance: N/A
    5. Density: 1.493g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.778
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine(885223-59-6)
    12. EPA Substance Registry System: 5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine(885223-59-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 885223-59-6(Hazardous Substances Data)

885223-59-6 Usage

Uses

Used in Medicinal Chemistry:
5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine is used as a building block for the synthesis of new pharmaceutical agents. Its unique structural features and functional groups make it a promising candidate for the development of novel drugs with potential therapeutic applications.
Used in Drug Discovery:
5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine is used as a starting material for the design and development of new drugs. Its chemical properties and potential interactions with biological targets make it a valuable resource for drug discovery efforts.
Further research and studies are required to explore the biological and pharmacological properties of 5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine and its potential uses in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 885223-59-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,2 and 3 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 885223-59:
(8*8)+(7*8)+(6*5)+(5*2)+(4*2)+(3*3)+(2*5)+(1*9)=196
196 % 10 = 6
So 885223-59-6 is a valid CAS Registry Number.

885223-59-6Downstream Products

885223-59-6Relevant articles and documents

2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics

Zeng, Qingping,Bourbeau, Matthew P.,Wohlhieter, G. Erich,Yao, Guomin,Monenschein, Holger,Rider, James T.,Lee, Matthew R.,Zhang, Shiwen,Lofgren, Julie,Freeman, Daniel,Li, Chun,Tominey, Elizabeth,Huang, Xin,Hoffman, Douglas,Yamane, Harvey,Tasker, Andrew S.,Dominguez, Celia,Viswanadhan, Vellarkad N.,Hungate, Randall,Zhang, Xiaoling

scheme or table, p. 1652 - 1656 (2010/07/15)

A series of 2-aminothiadiazole of inhibitors of AKT1 is described. SAR relationships are discussed, along with selectivity for protein kinase A (PKA) and cyclin-dependent kinase 2 (CDK2). Moderate selectivity observed in several compounds for AKT1 versus PKA is rationalized by X-ray crystallographic analysis. Key compounds showed activity in cellular assays measuring phosphorylation of two AKT substrates, PRAS40 and FKHRL1. Compound 30 was advanced to a mouse liver PD assay, where it showed dose-dependent inhibition of AKT activity, as measured by the inhibition of phospho-PRAS40.

THIADIAZOLE COMPOUNDS AND METHODS OF USE

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Page/Page column 23-25, (2010/11/08)

The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated

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