885275-00-3

Basic information

• Product Name: N-CBZ-4-IODOPIPERIDINE
• Synonyms: N-CBZ-4-IODOPIPERIDINE;1-Cbz-4-iodopiperidine;1-Piperidinecarboxylic acid, 4-iodo-, phenylMethyl ester;Benzyl 4-iodopiperidine-1-carboxylate
• CAS NO: 885275-00-3
• Molecular Formula: C₁₃H₁₆INO₂
• Molecular Weight: 345.18
• Mol File: 885275-00-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: N-CBZ-4-IODOPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CBZ-4-IODOPIPERIDINE(885275-00-3)
• EPA Substance Registry System: N-CBZ-4-IODOPIPERIDINE(885275-00-3)

Safety Data

• Hazardous Substances Data: 885275-00-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Manufacturing:
N-CBZ-4-IODOPIPERIDINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Scientific Research:
In the field of scientific research, N-CBZ-4-IODOPIPERIDINE serves as a crucial reagent for conducting experiments and exploring new chemical reactions. Its properties and behavior in different conditions provide valuable insights into the understanding of chemical processes and the development of innovative synthetic methods.
Used in Drug Discovery and Development:
N-CBZ-4-IODOPIPERIDINE is employed as a building block in the discovery and development of new drugs. Its unique chemical properties allow researchers to create novel molecular structures with potential therapeutic applications, thereby expanding the scope of available treatments for various diseases and conditions.
Used in Chemical Synthesis:
N-CBZ-4-IODOPIPERIDINE is utilized as a versatile reagent in chemical synthesis, enabling the creation of a wide range of complex organic compounds. Its ability to participate in various types of chemical reactions, such as substitution, addition, and elimination, makes it a valuable tool for chemists in the synthesis of new molecules with diverse applications.

Upstream product

• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 

Downstream Products

• 1105596-66-4 C₂₆H₄₁NO₂Si 
• 66207-23-6 1-benzyloxycarbonyl-1,2,3,6-tetrahydropyridine 
• 1624605-95-3 benzyl 4-(difluoromethyl)piperidine-1-carboxylate 
• 929974-12-9 2-piperidin-4-yl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1350606-93-7 benzyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)quinoxalin-2-yl)piperidine-1-carboxylate 
• 858670-79-8 (1-((benzyloxy)carbonyl)piperidin-4-yl)zinc(II) iodide 

Relevant articles and documents

Visible-Light-Mediated C-I Difluoroallylation with an α-Aminoalkyl Radical as a Mediator

Herein, we report a protocol for direct visible-light-mediated C-I difluoroallylation reactions of α-trifluoromethyl arylalkenes with alkyl iodides at room temperature with an α-aminoalkyl radical as a mediator. The protocol permits efficient functionalization of various α-trifluoromethyl arylalkenes with cyclic and acyclic primary, secondary, and tertiary alkyl iodides and is scalable to the gram level. This mild protocol uses an inexpensive mediator and is suitable for late-stage functionalization of complex natural products and drugs.

Triphenylphosphine-Catalyzed Alkylative Iododecarboxylation with Lithium Iodide under Visible Light

Under irradiation of 456 nm blue light-emitting diodes, PPh3 catalyzes the iododecarboxylation of aliphatic carboxylic acid derived N-(acyloxy)phthalimide with lithium iodide as an iodine source. The reaction delivers primary, secondary, and bridgehead te

Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni's Reagent

This work illustrates a reductive cross-electrophile coupling protocol for trifluoromethylation of alkyl iodides under Cu-catalyzed/Ni-promoted reaction conditions. The use of diboron esters as the terminal reductant allows the effective generation of the alkyl-CF3 products with excellent functional group tolerance and broad substrate scope. A mechanism involving a reaction of alkyl-Cu with Togni's reagent was proposed.

Discovery of clinical candidate 1-(4-(3-(4-(1 H-benzo[ d ]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A)

We report the identification of a PDE10A clinical candidate by optimizing potency and in vivo efficacy of promising keto-benzimidazole leads 1 and 2. Significant increase in biochemical potency was observed when the saturated rings on morpholine 1 and N-a

Nickel-catalyzed Negishi cross-couplings of secondary nucleophiles with secondary propargylic electrophiles at room temperature

(Chemical Equation Presented) Mild thing: The first nickel-based catalysts for cross-couplings of secondary organometallic nucleophiles with secondary alkyl electrophiles have been developed. Thus, Negishi reactions proceed under mild conditions (at room temperature with no basic activators) in the presence of NiCl2·glyme and a tridentate ligand (see scheme).