885275-07-0

Basic information

• Product Name: 1-(3,4-DIFLUORO-PHENYL)-PIPERIDIN-4-ONE
• Synonyms: 1-(3,4-DIFLUORO-PHENYL)-PIPERIDIN-4-ONE;CHEMBRDG-BB 4000316;1-(3,4-difluorophenyl)piperidin-4-one(SALTDATA: FREE)
• CAS NO: 885275-07-0
• Molecular Formula: C₁₁H₁₁F₂NO
• Molecular Weight: 211.21
• Product Categories: Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Piperidones
• Mol File: 885275-07-0.mol

Chemical Properties

• Boiling Point: 345.4°C at 760 mmHg
• Flash Point: 162.7°C
• Appearance: /
• Density: 1.267g/cm³
• Vapor Pressure: 6.15E-05mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3,4-DIFLUORO-PHENYL)-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-DIFLUORO-PHENYL)-PIPERIDIN-4-ONE(885275-07-0)
• EPA Substance Registry System: 1-(3,4-DIFLUORO-PHENYL)-PIPERIDIN-4-ONE(885275-07-0)

Safety Data

• Hazardous Substances Data: 885275-07-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11F2NO/c12-10-2-1-8(7-11(10)13)14-5-3-9(15)4-6-14/h1-2,7H,3-6H2

Upstream product

• 348-61-8 1-bromo-3,4-difluorobenzene 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 3863-11-4 3,4-difluoroaniline 
• 72548-31-3 1,5-Dichloropentan-3-ol 
• 263008-88-4 2'-O-[1-(3,4-Difluorophenyl)-4-methoxypiperidin-4-yl]uridine 

Downstream Products

• 263008-88-4 2'-O-[1-(3,4-Difluorophenyl)-4-methoxypiperidin-4-yl]uridine 
• 263008-81-7 1-(3,4-Difluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine 

Relevant articles and documents

NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.