885275-77-4Relevant articles and documents
Synthesis and Characterization of Axially Chiral Imidazoisoquinolin-2-ylidene Silver and Gold Complexes
Grande-Carmona, Francisca,Iglesias-Sigüenza, Javier,álvarez, Eleuterio,Díez, Elena,Fernández, Rosario,Lassaletta, José M.
, p. 5073 - 5080 (2015)
The selective Suzuki cross-coupling of 1,3-dichloroisoquinoline with 2-substituted 1-naphthylboronic acids/esters followed by construction of the imidazo[1,5-b]isoquinoline ring and alkylation constitutes a straightforward route to imidazolium salts fused into an axially chiral biaryl skeleton. Metalation of these azolium salts afforded the corresponding NHC silver complexes, which were used as carbene transfer agents for the synthesis of Au(I) derivatives.
FUSED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION METHODS THEREOF AND MEDICAL USES THEREOF
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Page/Page column 0246; 0260; 0270-0272; 0320; 0328; 0329, (2019/07/03)
The present invention relates to fused heterocyclic derivatives, processes for their preparation and their use in medicine. Specifically, the present invention relates to a novel derivative represented by the formula (I′), or its pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the derivative or its pharmaceutically acceptable salt thereof, and the method for preparing the derivative and its pharmaceutically acceptable salt thereof. The present invention also relates to the use of the derivative and its pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the derivative and its pharmaceutically acceptable salt thereof in the preparation of medicines, in particularly as IDO inhibitor medicines, for treating and/or preventing cancers. Wherein each substituent of the formula (I′) is the same as defined in the specification.