885277-59-8

Basic information

• Product Name: 1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE
• Synonyms: 1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE;1-Pyrrolidinecarboxylic acid, 2,5-bis(hydroxymethyl)-, 1,1-dimethylethyl ester;EOS-61185
• CAS NO: 885277-59-8
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.29
• Mol File: 885277-59-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE(885277-59-8)
• EPA Substance Registry System: 1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE(885277-59-8)

Safety Data

• Hazardous Substances Data: 885277-59-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE is used as a reagent for the protection and deprotection of amino groups in peptide synthesis. The BOC protecting group allows for selective reactions with other functional groups, facilitating the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE is utilized as a key intermediate in the synthesis of various drugs. Its versatile reactivity and functional groups contribute to the development of new medications with improved efficacy and reduced side effects.
Used in Specialty Chemicals:
1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE is also employed in the production of specialty chemicals, where its unique structure and reactivity are harnessed to create high-value compounds for specific applications, such as advanced materials and catalysts.

Upstream product

• 92197-46-1 (1-benzyl-5-hydroxymethyl-pyrrolidine-2-yl)-methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 54221-37-3 diethyl meso-2,5-dibromoadipate 
• 17740-40-8 diethyl meso-1-benzyl-2,5-pyrrolidinedicarboxylate 

Downstream Products

• 149771-43-7 3-benzyl-8-(tert-butoxycarbonyl)-3,8-diazabicyclo[3.2.1]-octane 
• 1354947-77-5 1,1-dimethylethyl 2-(hydroxymethyl)-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1-pyrrolidinecarboxylate 

Relevant articles and documents

Synthesis method of 2, 5-pyrrolidine dimethyl carbinol and derivatives thereof

The invention provides a synthetic method of 2, 5-pyrrolidine dimethyl carbinol and derivatives thereof, and belongs to the field of organic synthesis. The synthesis method of 2, 5-pyrrolidine dimethyl carbinol is characterized in that a reaction equation is shown in the specification; in the formula, PG1 is selected from any one of H, benzyl, carbobenzoxy, triphenylmethyl or p-methoxybenzyl, and Cat. is a hydrogenation catalyst. The method comprises the following reaction step that: step 1, a compound 1, the hydrogenation catalyst and H2 contact with one another to obtain a compound 2. According to the method, 2, 5-dicarboxaldehyde pyrrole is selected as a reaction starting raw material, and the specific hydrogenation catalyst is selected, so that the 2, 5-pyrrolidine dimethyl carbinol can be obtained in a one-step reduction and high-yield manner, and the production cost is effectively reduced.

ROR [gamma]t inhibitor, preparation method and application thereof

The invention relates to the technical field of medicines, in particular to an ROR [gamma]t inhibitor, a preparation method and application thereof. The invention also relates to a pharmaceutical composition containing the compound, a method for preparing the pharmaceutical composition, and application of the compound or the pharmaceutical composition in treatment or prevention of ROR [gamma]t-mediated cancers, inflammations or autoimmune diseases of mammals, especially human beings.

An improved and scalable process for 3,8-diazabicyclo[3.2.1]octane analogues

An improved and scalable process for substituted 3,8-diazabicyclo[3.2.1] octane was developed. N-Benzyl-2,5-dicarbethoxy-pyrrolidine 2 was reduced to N-benzyl-2,5-dihydroxymethylpyrrolidine 9 and subsequently debenzylated to afford N-Boc-2,5-dihydroxymeth