3-(5-)-Amino-o-diarylisoxazoles: Regioselective synthesis and antitubulin activity
A regioselective synthesis of both 5-amino- and 3-aminodiarylisoxazoles substituted with polyalkoxyaryl pharmacophores has been validated. Starting materials for the synthetic scheme were easily available from plant extracts. The targeted molecules were f
Tsyganov, Dmitry V.,Khrustalev, Victor N.,Konyushkin, Leonid D.,Raihstat, Mikhail M.,Firgang, Sergei I.,Semenov, Roman V.,Kiselyov, Alex S.,Semenova, Marina N.,Semenov, Victor V.
p. 112 - 125
(2014/01/17)
NOVEL COMPOUNDS AND THEIR USE IN THERAPY
The invention provides compounds which inhibit N-myristoyltransferase and are selective for protozoal N-myristoyltransferase and, consequently suitable to treat microbial infections, including viral and fungal infections, and protozoan infections such as malaria, leishmaniasis and sleeping sickness.
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Page/Page column 103
(2013/06/27)
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