886368-65-6 Usage
Uses
Used in Pharmaceutical Industry:
2-(4-TRIFLUOROMETHOXY-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activities. Its unique structure allows it to be involved in a range of chemical reactions, making it a valuable component in the development of new drugs with therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical field, 2-(4-TRIFLUOROMETHOXY-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID is used as a building block in the creation of compounds for crop protection. Its incorporation into agrochemicals can contribute to the development of effective solutions for pest and disease control, enhancing agricultural productivity and crop safety.
Check Digit Verification of cas no
The CAS Registry Mumber 886368-65-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,3,6 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 886368-65:
(8*8)+(7*8)+(6*6)+(5*3)+(4*6)+(3*8)+(2*6)+(1*5)=236
236 % 10 = 6
So 886368-65-6 is a valid CAS Registry Number.
886368-65-6Relevant articles and documents
Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives
Kort, Michael E.,Atkinson, Robert N.,Thomas, James B.,Drizin, Irene,Johnson, Matthew S.,Secrest, Matthew A.,Gregg, Robert J.,Scanio, Marc J.C.,Shi, Lei,Hakeem, Ahmed H.,Matulenko, Mark A.,Chapman, Mark L.,Krambis, Michael J.,Liu, Dong,Shieh, Char-Chang,Zhang, Xufeng,Simler, Gricelda,Mikusa, Joseph P.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Roeloffs, Rosemarie,Werness, Stephen,Antonio, Brett,Marsh, Kennan C.,Faltynek, Connie R.,Krafte, Douglas S.,Jarvis, Michael F.,Marron, Brian E.
scheme or table, p. 6812 - 6815 (2011/01/04)
A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Nav1.8 sodium channel is reported. Replacement of the furan nucleus and homologation of the anilide linker in subtype-selective blocker A-803467 (1) provided potent, selective derivatives with improved aqueous solubility and oral bioavailability. Representative compounds from this series displayed efficacy in rat models of inflammatory and neuropathic pain.
