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Tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate is a chemical compound with the molecular formula C17H24FN3O2. It is an ester derivative of piperazine, featuring a tert-butyl group and a 4-fluorophenyl group attached to the piperazine ring. tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate is widely recognized for its role in medicinal and pharmaceutical research, serving as a key building block for the synthesis of diverse bioactive molecules and pharmaceutical drugs. Its potential pharmacological properties, such as its antipsychotic and anxiolytic effects, have been the subject of study, with additional possibilities for its application in the treatment of neurological disorders and related conditions.

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  • 886767-25-5 Structure
  • Basic information

    1. Product Name: tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate
    2. Synonyms: tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate;1-BOC-3-(4-FLUOROPHENYL)PIPERAZINE;Tert-Butyl 3-(4-Fluorophenylpiperazine-1-
    3. CAS NO:886767-25-5
    4. Molecular Formula: C15H21FN2O2
    5. Molecular Weight: 280.3378432
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 886767-25-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 370.4±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.125±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: 7?+-.0.40(Predicted)
    10. CAS DataBase Reference: tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate(886767-25-5)
    12. EPA Substance Registry System: tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate(886767-25-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 886767-25-5(Hazardous Substances Data)

886767-25-5 Usage

Uses

Used in Pharmaceutical Research:
Tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate is utilized as a chemical intermediate for the synthesis of various bioactive molecules and pharmaceutical drugs. Its unique structure allows for the development of compounds with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate is employed as a precursor in the design and synthesis of new drugs. Its versatility in chemical reactions enables the creation of a range of molecules with different pharmacological profiles.
Used in Neurological Disorders Treatment:
Tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate is studied for its potential applications in the treatment of neurological disorders. Its pharmacological properties, such as its antipsychotic and anxiolytic effects, make it a promising candidate for further research and development in this area.
Used in Drug Development for Anxiety and Psychosis:
tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate is considered for use as a drug development candidate for conditions such as anxiety and psychosis. Its potential as an anxiolytic and antipsychotic agent is currently under investigation, with the aim of identifying new treatment options for these mental health disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 886767-25-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,7,6 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 886767-25:
(8*8)+(7*8)+(6*6)+(5*7)+(4*6)+(3*7)+(2*2)+(1*5)=245
245 % 10 = 5
So 886767-25-5 is a valid CAS Registry Number.

886767-25-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 3-(4-fluorophenyl)piperazine-1-carboxylate

1.2 Other means of identification

Product number -
Other names 1-BOC-3-(4-FLUOROPHENYL)PIPERAZINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:886767-25-5 SDS

886767-25-5Downstream Products

886767-25-5Relevant articles and documents

ANTAGONISTS OF GPR39 PROTEIN

-

Page/Page column 201-202, (2021/11/06)

Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

Iridium-catalyzed Synthesis of Saturated N-Heterocycles from Aldehydes and SnAP Reagents with Continuous Flow Photochemistry

Jindakun, Chalupat,Hsieh, Sheng-Ying,Bode, Jeffrey W.

supporting information, p. 2071 - 2075 (2018/04/16)

Commercially available tin amine protocol (SnAP) reagents provide a simple approach to the synthesis of a wide variety of saturated N-heterocycles from aldehydes. In this report, we disclose that the copper(II) promoter and hexafluoroisopropanol can be replaced by photocatalytic conditions using Ir[dF(CF3)ppy]2(dtbbpy)PF6 in CH3CN. Continuous flow photochemical conditions provide a clean, scalable approach to valuable products including morpholines, piperazines, thiomorpholines, diazepanes, and oxazepanes from aldehyde starting materials.

Piperazine derivatives and the use thereof as medicament

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Paragraph 0302; 0303; 0304; 0305; 0306, (2015/04/21)

The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).

PIPERAZINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT

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Page/Page column 65; 66, (2015/05/05)

The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).

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