- Synthesis method of 3-ethoxy-4-ethoxycarbonyl phenylacetic acid
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The invention relates to a synthesis method of 3-ethoxy-4-ethoxycarbonyl phenylacetic acid, and belongs to the technical field of medicine synthesis. In order to solve the problems of long reaction route and low yield in the prior art, the invention provides the synthesis method of 3-ethoxy-4-ethoxycarbonyl phenylacetic acid, which comprises the following steps: under the actions of a catalytic amount of phase transfer catalyst and cocatalyst, carrying out etherification and esterification reaction on 4-methylsalicylic acid and diethyl carbonate in a water-insoluble solvent to obtain a corresponding intermediate is obtained, in the presence of lithium diisopropylamide, carrying out methylation reaction on the intermediate and dimethyl carbonate or diethyl carbonate at the temperature of -50 DEG C or below, and carrying out acid regulation treatment to control the pH value of the system to be 3.5 or below, thereby obtaining the corresponding product compound 3-ethoxy-4-ethoxycarbonylphenylacetic acid shown in the formula III. According to the method, the operation of each step of reaction post-treatment is simple and easy, the method has the advantage of short reaction route, and the yield of the final product is high.
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Paragraph 0036-0037; 0039-0040; 0042-0043; 0045-0046
(2021/01/24)
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- GLUCOSE UPTAKE INHIBITORS
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this invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUTS3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are useful for treating diseases, including cancer, autoimmune diseases and inflammation, infectious diseases, and metabolic diseases.
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Paragraph 01083; 01088-01090; 01103; 01108-01110
(2020/01/24)
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