887120-96-9

Basic information

• Product Name: tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate
• Synonyms: tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate;1'-Boc-spiro[hydantoin-5,3'-piperidine]
• CAS NO: 887120-96-9
• Molecular Formula: C12H19N3O4
• Molecular Weight: 269.29696
• Mol File: 887120-96-9.mol

Chemical Properties

• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 10.00±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate(887120-96-9)
• EPA Substance Registry System: tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate(887120-96-9)

Safety Data

• Hazardous Substances Data: 887120-96-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate is used as a building block in organic synthesis for the creation of various biologically active compounds due to its unique spirocyclic structure and functional groups.
Used in Pharmaceutical Research:
In pharmaceutical research, tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate is utilized as an intermediate for the development of potential pharmaceuticals, leveraging its ability to display diverse pharmacological activities.
Used in Antibacterial Applications:
Tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate is used as an antibacterial agent, given its potential to combat bacterial infections, making it a subject of interest in the development of new antimicrobial drugs.
Used in Antifungal Applications:
Similarly, in antifungal applications, tert-butyl 2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7-carboxylate is employed for its potential to inhibit fungal growth, contributing to the advancement of new antifungal medications.

Upstream product

• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 506-87-6 ammonium carbonate 

Downstream Products

• 923010-98-4 C₁₉H₃₂N₄O₄ 
• 923011-54-5 C₂₀H₃₄N₄O₄ 
• 1042441-62-2 tert-butyl 4-(3-isopropyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidine-1-carboxylate 

Relevant articles and documents

Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space

Fragment-based drug design has been successfully applied to a large set of proteins, however in order to expand this concept to the most demanding targets, such as protein-protein interactions, it is required to enrich current fragment libraries with new and original 3D privileged fragments. Our goal was to develop a rapid microwave-assisted synthesis of 27 new privileged spirohydantoin fragments. Among them 24 compounds showed a high water solubility. These molecules were plotted according to the normalized principal moments of inertia of their minimized conformers, and most of the compounds were prone to occupy under-populated regions of the triangular plot. Finally we demonstrated that the hydantoin ring can be selectively N-monoalkylated providing the access to rapid functionalization for further elaboration.

8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS

Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and / or systemic lupus