The invention relates to a composition for controlling endoparasites in and on animals, which comprises a combination of (A) a compound of formula (I) and (B) paraherquamide A or a derivative or analogue thereof, wherein X and Y are as defined in the claims. The compositions are useful in the control of endoparasites, in particular helminths, in and on warm-blooded animals.
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(2011/05/05)
Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds
A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented.
PROCESS FOR THE PREPARATION OF ENANTIOMERS OF AMIDOACETONITRILE COMPOUNDS FROM THEIR RACEMATES
The invention is directed at a new process for the preparation of pure enantiomers from the racemate of amidoacetonitrile compounds of formula (I) wherein R1, R2 and R3, independently of each other, signify hydrogen, halog
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Page/Page column 8
(2008/06/13)
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