Synthesis and structure–activity relationships of aristoyagonine derivatives as brd4 bromodomain inhibitors with x-ray co-crystal research
Epigenetic regulation is known to play a key role in progression of anti-cancer therapeutics. Lysine acetylation is an important mechanism in controlling gene expression. There has been increasing interest in bromodomain owing to its ability to modulate t
Synthesis of dibenzoxepine lactams via a Cu-catalyzed one-pot etherification/aldol condensation cascade reaction: Application toward the total synthesis of aristoyagonine
A general synthesis of dibenzoxepine lactams has been developed using a one-pot Cu-catalyzed etherification/aldol condensation cascade reaction. The reaction of 4-hydroxyisoindolin-1-one with a wide range of 2-bromobenzaldehydes in the presence of a copper catalyst provided various aristoyagonine derivatives in good yields.
Lim, Hye Sun,Choi, Young Lok,Heo, Jung-Nyoung
supporting information
p. 4718 - 4721
(2013/10/08)
Studies on tetrahydroisoquinolines. XXV. A synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines; Total synthesis of (±)-cherylline
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Hara,Shirai,Hoshino,Umezawa
p. 3107 - 3112
(2007/10/02)
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