88745-30-6Relevant articles and documents
Substituted 2-aminonicotinonitriles
Troschutz,Dennstedt
, p. 85 - 89 (2007/10/02)
Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.
57. SYNTHESIS, PROTONATION, AND ACID-BASE PROPERTIES OF CONDENSED DERIVATIVES OF 4-OXO-1,4-DIHYDRO-1,8-NAPHTHYRIDINE
Guss, L. T.,Khabarova, L. S.,Ershov, L. V.,Dvoryantseva, G. G.,Proshina, N. N.,Granik, V. G.
, p. 544 - 551 (2007/10/02)
A number of 4-oxo-1,4-dihydro-1,8-naphthyridine derivatives that differ with respect to the sizes of the aza- and carbocycles were synthesized by the reaction of 3-amino-4-ethoxycarbonyl-5,6,7,8-tetrahydroisoquinoline with N,N-dimethylacetamide diethylacetal and subsequent cyclization of the intermediate amidines.It was established by UV and 1H and 13C NMR spectroscopy that the protonation of these compounds takes place at the exocyclic oxygen atom.The dependence of the ionization constants of the compounds obtained in 70 percent DMFA on the size of the saturated cyclic fragments of the molecules was established.
ACETALS OF LACTAMS AND ACID AMIDES. 39. SYNTHESIS OF THREE-RING DERIVATIVES OF PYRIDOPYRIMIDINES ON THE BASIS OF THE REACTION OF DIMETHYLFORMAMIDE ACETAL WITH DICYANOMETHYLENECYCLOALKANES
Granik, V. G.,Smetskaya, N. I.,Mukhina, N. A.,Persianova, I. V.,Klimenko, V. G.
, p. 1027 - 1030 (2007/10/02)
The reaction of dicyanomethylenecyclopentane and -cyclohexane with dimethylformamide diethylacetal was used to synthesize dieneamino nitriles, from which isoquinoline and 2-pyridine derivatives were obtained by treatment with ammonia.The reaction of 3-ami
