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CAS

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887595-25-7

1-(3-NITRO-PHENYL)-AZEPANE, with the molecular formula C13H17NO2, is a chemical compound belonging to the azepane family. It features a nitrophenyl group, which contributes to its significance in various fields. 1-(3-NITRO-PHENYL)-AZEPANE is known for its potential applications in organic synthesis and pharmaceutical research, where it serves as a building block for creating new compounds with possible biological activities.

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  • 887595-25-7 Structure

  • Basic information

    1. Product Name: 1-(3-NITRO-PHENYL)-AZEPANE
    2. Synonyms: 1-(3-NITRO-PHENYL)-AZEPANE
    3. CAS NO:887595-25-7
    4. Molecular Formula: C12H16N2O2
    5. Molecular Weight: 220.27
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 887595-25-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(3-NITRO-PHENYL)-AZEPANE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(3-NITRO-PHENYL)-AZEPANE(887595-25-7)
    11. EPA Substance Registry System: 1-(3-NITRO-PHENYL)-AZEPANE(887595-25-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 887595-25-7(Hazardous Substances Data)

887595-25-7 Usage

Uses

Used in Pharmaceutical Research:
1-(3-NITRO-PHENYL)-AZEPANE is used as a building block for the development of new compounds with potential biological activity. Its nitro group plays a crucial role in the creation of drugs and other organic materials, making it an important component in pharmaceutical research.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(3-NITRO-PHENYL)-AZEPANE is utilized as a key component for synthesizing a variety of functionalized organic molecules. Its unique structure and properties allow for the formation of diverse compounds with potential applications in various industries.
Used in Materials Science:
1-(3-NITRO-PHENYL)-AZEPANE may also find applications in the field of materials science, where it can be used as a precursor for the synthesis of novel materials with specific properties. Its versatility and the presence of the nitro group make it a valuable asset in the development of advanced materials.

Check Digit Verification of cas no

The CAS Registry Mumber 887595-25-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,7,5,9 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 887595-25:
(8*8)+(7*8)+(6*7)+(5*5)+(4*9)+(3*5)+(2*2)+(1*5)=247
247 % 10 = 7
So 887595-25-7 is a valid CAS Registry Number.

887595-25-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-Nitrophenyl)azepane

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:887595-25-7 SDS

887595-25-7Downstream Products

887595-25-7Relevant articles and documents

Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents

Shao, Hao,Foley, David W.,Huang, Shiliang,Abbas, Abdullahi Y.,Lam, Frankie,Gershkovich, Pavel,Bradshaw, Tracey D.,Pepper, Chris,Fischer, Peter M.,Wang, Shudong

supporting information, (2021/02/16)

Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the conserved ATP binding site, designing selective CDK9 inhibitors has been challenging. Here we report our continued efforts in the optimization of 2,4,5-tri-substituted pyrimidine compounds as potent and selective CDK9 inhibitors. The most selective compound 30m was >100-fold selective for CDK9 over CDK1 and CDK2. These compounds showed broad anti-proliferative activities in various solid tumour cell lines and patient-derived chronic lymphocytic leukaemia (CLL) cells. Decreased phosphorylation of the carboxyl terminal domain (CTD) of RNAPII at Ser-2 and down-regulation of anti-apoptotic protein Mcl-1 were confirmed in both the ovarian cancer model A2780 and patient-derived CLL cells.

DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS

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Paragraph 71; 113; 121, (2018/12/02)

The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

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