Methotrexate Analogues. 21. Divergent Influence of Alkyl Chain Length on the Dihydrofolate Reductase Affinity and Cytotoxicity of Methotrexate Monoesters
n-Octyl, n-dodecyl, and n-hexadecyl α- and γ-esters of methotrexate (MTX) were compared with the previously described α- and γ-n-butyl esters and with MTX as inhibitors of dihydrofolate reductase (DHFR) and human leukemic lymphoblasts (CEM cells) in cultu
Rosowsky, Andre,Forsch, Ronald A.,Yu, Cheng-Sein,Lazarus, Herbert,Beardsley, G. Peter
p. 605 - 609
(2007/10/02)
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