889940-03-8

Basic information

• Product Name: 1-PHENETHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID
• Synonyms: 1-PHENETHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID;1-(2-phenylethyl)-1H-1,2,3-triazole-4-carboxylic acid
• CAS NO: 889940-03-8
• Molecular Formula: C₁₁H₁₁N₃O₂
• Molecular Weight: 217.22
• Mol File: 889940-03-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-PHENETHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENETHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID(889940-03-8)
• EPA Substance Registry System: 1-PHENETHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID(889940-03-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 889940-03-8(Hazardous Substances Data)

Usage

Chemical classification

1-PHENETHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID is a chemical compound that belongs to the family of carboxylic acids and triazoles.

Potential applications

It is known for its potential applications in pharmaceutical and agrochemical industries.

Use as a building block

The compound is suitable for use as a building block in the synthesis of various organic molecules, including potential drug candidates and crop protection agents.

Structural components

Its structure includes a phenethyl group, a triazole ring, and a carboxylic acid functional group.

Unique chemical properties

The presence of the phenethyl group, triazole ring, and carboxylic acid functional group contribute to its unique chemical properties.

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
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Relevant articles and documents

Highly regioselective and sustainable solar click reaction: A new post-synthetic modified triazole organic polymer as a recyclable photocatalyst for regioselective azide-alkyne cycloaddition reaction

The synthesis of pharmaceutically active 1,2,3-triazoles has been continuously scrutinized in the search for unique and effective catalysts to make the process efficient, green, and sustainable. Here, we are presenting a new visible light active Ni(ii) cyclam-integrated triazole-linked organic polymer (Ni-TLOP) photocatalyst for the synthesis of 1,2,3-triazole compounds with excellent efficiency and regioselectivity. The reaction was studied for a series of substrates and the absolute regioselectivity of a representative triazole product has also been confirmed by X-ray crystallography. The proficiency and chemical orthogonality of the Ni-TLOP are remarkable and it shows enhanced efficiency and regioselectivity. The use of a recyclable photocatalyst and non-hazardous reagents makes the catalytic system sustainable and environmentally friendly. This photocatalyzed click reaction technique has been successfully applied to the expedient synthesis of one of the most sold anti-epileptic drugs rufinamide.

S-Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C-Alkylation

A tandem enzymatic strategy to enhance the scope of C-alkylation of small molecules via the in situ formation of S-adenosyl methionine (SAM) cofactor analogues is described. A solvent-exposed channel present in the SAM-forming enzyme SalL tolerates 5′-chloro-5′-deoxyadenosine (ClDA) analogues modified at the 2-position of the adenine nucleobase. Coupling SalL-catalyzed cofactor production with C-(m)ethyl transfer to coumarin substrates catalyzed by the methyltransferase (MTase) NovO forms C-(m)ethylated coumarins in superior yield and greater substrate scope relative to that obtained using cofactors lacking nucleobase modifications. Establishing the molecular determinants that influence C-alkylation provides the basis to develop a late-stage enzymatic platform for the preparation of high value small molecules.

TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS

Provided herein are compounds of the formulas:. which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including cancer, e

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Hsp90 C-terminal inhibitors are advantageous for the development of new cancer chemotherapeutics due to their ability to segregate client protein degradation from induction of the prosurvival heat shock response, which is a major detriment associated with