A mild acid-free one-pot reaction for synthesis of new phenanthridine dyes
A series of new phenylphenanthridin dyes have been synthesized in the yields of 52–75% by a mild strategy in one-pot reaction. This is the first successful attempt to perform efficient soft acid-free reaction for phenanthridine ring construction. A large substrate scope was well demonstrated.
Free-amine directed arylation of biaryl-2-amines with aryl iodides by palladium catalysis
A new palladium-catalyzed free-amine directed arylation of C(sp 2)-H bonds in the presence of AgOAc and TFA is described. Biaryl-2-amines react with various aryl iodides to give the corresponding mono- or diarylated products with exclusive regioselectivity.
Pd(II)-catalyzed C(sp2)-H carbonylation of biaryl-2-amine: Synthesis of phenanthridinones
A Pd(OAc)2-catalyzed C(sp2)-H carbonylation protocol of arenes under carbon monoxide atmosphere has been developed. The scope of the carbonylation reaction is broad and tolerates a variety of useful functional groups. This reaction provides a novel and efficient method for the synthesis of biologically and pharmaceutically significant phenanthridinones.