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N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • METHANESULFONAMIDE,N-[4-(4-FLUOROPHENYL)-6-(1-METHYLETHYL)-5-[(1E)-3-OXO-1-PROPEN-1-YL]-2-PYRIMIDINYL]-N-METHYL-

    Cas No: 890028-66-7

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  • Methanesulfonamide, N-[4-(4-fluorophenyl)-6-(1-methylethyl)-5-[(1E)-3-oxo-1-propenyl]-2-pyri midinyl]-N-methyl- CAS 890028-66-7 CAS no 890028-66-7

    Cas No: 890028-66-7

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  • N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide

    Cas No: 890028-66-7

  • USD $ 10.0-10.0 / Milligram

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  • 890028-66-7 Structure
  • Basic information

    1. Product Name: N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide
    2. Synonyms: N-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide;N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide;MethanesulfonaMide,N-[4-(4-fluorophenyl)-6-(1-Methylethyl)-5-[(1E)-3-oxo-1-propen-1-yl]-2-pyriMidinyl]-N-Methyl-;N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-3-oxo-1-propen-1-yl]-2-pyrimidinyl]-N-methylmethanesulfonamide;N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMi;(E)-N-(4-(4-Fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-en-1-yl)pyrimidin-2-yl)-N-methylmethanesulfonamide
    3. CAS NO:890028-66-7
    4. Molecular Formula: C18H20FN3O3S
    5. Molecular Weight: 377.4331032
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 890028-66-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 579.4±60.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.289±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: Dichloromethane, Ethyl Acetate, Methanol
    9. PKA: -1.10±0.10(Predicted)
    10. CAS DataBase Reference: N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide(890028-66-7)
    12. EPA Substance Registry System: N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide(890028-66-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 890028-66-7(Hazardous Substances Data)

890028-66-7 Usage

Uses

Rosuvastatin (R700500) intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 890028-66-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,0,2 and 8 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 890028-66:
(8*8)+(7*9)+(6*0)+(5*0)+(4*2)+(3*8)+(2*6)+(1*6)=177
177 % 10 = 7
So 890028-66-7 is a valid CAS Registry Number.

890028-66-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-(4-fluorophenyl)-5-[(E)-3-oxoprop-1-enyl]-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

1.2 Other means of identification

Product number -
Other names N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-3-oxo-1-propenyl]-2-pyrimidinyl]-N-methyl-methanesulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:890028-66-7 SDS

890028-66-7Relevant articles and documents

A (E)- 3 - [4 - (4 - fluorophenyl) - 6 - isopropyl - 2 - (N - methyl - N - a sulfuryl amidogen) pyrimidine - 5 - yl] acrolein synthetic method

-

, (2017/11/23)

The invention discloses a method for synthesizing (E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methane sulfonamide) pyrimidine-5-yl] acraldehyde used as a rosuvastatin calcium intermediate. The synthesizing method comprises the following steps: reacting a compound in formula III with substituted sulphonate or substituted sulfinic acid ester in the existence of a metal reagent, generating a compound in a formula II under the effect of an eliminating reagent and converting into a product, wherein in the formula II, R is chosen from -CN. The method is simple in process and low in cost, the expensive catalyst is avoided and the byproduct is effectively reduced, so that the after treatment is simple and easy to operate, the reaction yield is greatly increased and the method is suitable for large scale industrial production. The formulae are as shown in the specification.

A (E)- 3 - [4 - (4 - fluorophenyl) - 6 - isopropyl - 2 - (N - methyl - N - a sulfuryl amidogen) pyrimidine - 5 - yl] acrolein preparation method

-

, (2017/07/04)

The invention discloses a preparation method of (E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino) pyrimidine-5-yl] acrolein which can be used as a rosuvastatin intermediate. The preparation method comprises the following steps: reacting 4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino) pyrimidine-5-yl-formaldehyde with a sulfur ylide reagent under an alkaline condition to generate an epoxide shown in the formula III; then, reducing in the presence of a metal catalyst to generate a compound shown in the formula II; and finally reacting the compound shown in the formula II to generate the target product. The preparation method is simple in process and low in cost; no expensive catalyst is used; the generation of byproducts is reduced effectively so that the post-treatment becomes simple and easy to operate; in addition, the reaction yield is improved greatly; and therefore, the preparation method is quite suitable for large-scale industrial production.

PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

-

, (2012/02/13)

The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

-

, (2012/03/26)

The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

Process for preparing pyrimidine propenaldehyde

-

Page/Page column 11, (2011/08/04)

The present invention relates to an improved process for preparing (2E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-propenal of formula (I), which is an useful intermediate in the preparation of Rosuvastatin.

AN IMPROVED PROCESS FOR PREPARING PYRIMIDINE PROPENALDEHYDE

-

Page/Page column 19-20, (2010/04/27)

The present invention relates to an improved process for preparing (2E)-3-[4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]- propenal of formula (I), which is an useful intermediate in the preparation of Rosuvastatin.

PROCESS FOR PREPARING ROSUVASTATIN CALCIUM

-

Page/Page column 11, (2010/03/31)

The present invention relates to an improved process for preparing Rosuvastatin calcium of Formula I.

PROCESS FOR PREPARING ROSUVASTATIN CALCIUM

-

Page/Page column 9, (2010/03/02)

The present invention relates to an improved process for preparing (2E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-propenal of Formula I which is an intermediate useful in the preparation of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methyl-sulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoicacid] calcium salt of Formula II

PROCESS FOR THE PREPARATION OF ROSUVASTATIN

-

Page/Page column 33-34; 8, (2008/12/06)

A process for the manufacture of a compound of formula (V), useful for making rosuvastatin, by a stereoselective aldol reaction is described.

AN IMPROVED PROCESS FOR PREPARING ROSUVASTATIN CACLIUM

-

Page/Page column 18, (2008/12/06)

The present invention relates to an improved process for preparing (2E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-propenal of Formula I which is an intermediate useful in the preparation of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoicacid] calcium salt of Formula II

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