This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.
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Page/Page column 56
(2012/11/13)
Ethyl cyanoacetate: A new cyanating agent for the palladium-catalyzed cyanation of aryl halides
A new Pd-catalyzed cyanation reaction has been discovered using ethyl cyanoacetate as the cyanating reagent. A variety of electron-rich and electron-deficient aryl halides were efficiently converted into their corresponding nitriles in good to excellent yields.
Zheng, Shuyan,Yu, Chunhui,Shen, Zhengwu
supporting information; experimental part
p. 3644 - 3647
(2012/08/28)
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