- Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA α5 inverse agonists with potential for the treatment of cognitive dysfunction
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In a search for GABAA α5 ligands that combine high subtype binding selectivity with a marked inverse agonism imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines were identified as a promising class. A short tandem reaction allowed rapid a
- Buettelmann, Bernd,Ballard, Theresa M.,Gasser, Rodolfo,Fischer, Holger,Hernandez, Maria-Clemencia,Knoflach, Frederic,Knust, Henner,Stadler, Heinz,Thomas, Andrew W.,Trube, Gerhard
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scheme or table
p. 5958 - 5961
(2010/08/22)
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- Substituted imidazo[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives
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The present invention is concerned with substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of the formula I wherein R1 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkox
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Page/Page column 22
(2010/11/08)
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