Synthesis of cicerfuran, an antifungal benzofuran, and some related analogues
Routes were investigated for the synthesis of cicerfuran, a hydroxylated benzofuran from wild chickpea implicated in resistance to Fusarium wilt, and some of its analogues. A novel method is described for the synthesis of oxygenated benzofurans by epoxidation and cyclisation of 2′-hydroxystilbenes. The stilbene intermediates required could be synthesised by palladium-catalysed coupling of styrenes with mono-oxygenated aryl halides but not with di-oxygenated aryl halides. Stilbenes corresponding to the latter were synthesised by Wittig reactions.
Aslam, Shazia N.,Stevenson, Philip C.,Phythian, Sara J.,Veitch, Nigel C.,Hall, David R.
p. 4214 - 4226
(2007/10/03)
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