- BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN
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Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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Paragraph 00766; 00779
(2014/06/11)
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- Substitution Reactions Under NH3 Chemical Ionization Conditions in cis-/trans-1,2-Dihydroxybenzosuberans
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The nucleophilic substitution reaction under NH3 chemical ionization (CI) conditions in cis- and trans-1,2-dihydroxybenzosuberans (1-4) has benn studied with the help ND3 CI and metastable data.The results indicate that in the parent diols 1 (cis) and 2 (trans), the substitution ion, sH>+, is produced mainly by the loss of H2O from the + ion (SNi reaction) while in their 7-methoxy derivatives 3 and 4, the ion-molecule reaction between + and NH3 seems to be the major pathway for the formation of sH>+.The substitution ion from 1 and 2 and the + ion from trans-1-amino-2-hydroxybenzosuberan give similar collision-induced dissociation mass-analysed ion kinetic energy spectra.Interestingly, their diacetates do not undergo the substitution reaction.
- Madhusudanan, K. P.,Prasad, Mohan,Rastogi, Shri Nivas,Fraisse, D.
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p. 680 - 684
(2007/10/02)
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- Compounds with Bridgehead Nitrogen. Part 47. The Reaction between trans-1-Aminobenzocycloalkan-2-ols and Formaldehyde
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The reaction between trans-1-aminoindan-2-ol and formaldehyde and between trans-1-amino-1,2,3,4-tetrahydronaphthalen-2-ol and formaldehyde yields 5,r-5a,t-8a,13,c-13a,t-16a-hexahydro-8,16-methanodi-indenodioxadiazecine and 5,6,r-6a,c-9a,14,15,t-15a,t-18a-octahydro-9,18-methanodinaphthodioxadiazecine respectively whereas the reaction between trans-1-amino-2-hydroxy-6,7,8,9-tetrahydro-5H-benzocycloheptane and formaldehyde yields bis(1,3a,4,5,6,10b-hexahydro-2H-benzocycloheptoxazol-1-yl)methanes.
- Barkworth, Peter M. R.,Crabb, Trevor A.,Robinson, Paul
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p. 2807 - 2810
(2007/10/02)
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