892414-47-0

Basic information

• Product Name: 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine;3--trifluoromethyl-7-azaindole;3-(trifluoroMethyl)-1H-pyrrolo[2,3;3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-4;3-(Trifluoromethyl)-1H-pyrrolo[2,3-b]
• CAS NO: 892414-47-0
• Molecular Formula: C₈H₅F₃N₂
• Molecular Weight: 186.1339096
• Product Categories: Non-Chiral heterocyclic compounds
• Mol File: 892414-47-0.mol

Chemical Properties

• Appearance: /
• Density: 1.447±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• PKA: 12.04±0.40(Predicted)
• CAS DataBase Reference: 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine(892414-47-0)
• EPA Substance Registry System: 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine(892414-47-0)

Safety Data

• Hazardous Substances Data: 892414-47-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine is utilized as a key building block in the synthesis of various pharmaceuticals. Its unique structure and properties contribute to the development of new drugs with enhanced efficacy and selectivity, making it an invaluable asset in medicinal chemistry research.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine serves as a crucial component in the synthesis of agrochemicals. Its distinctive chemical properties allow for the creation of novel compounds with improved pesticidal or herbicidal activities, thereby contributing to more effective crop protection strategies.
Used in Materials Science:
3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine is employed in materials science for its potential to contribute to the development of new materials with unique properties. Its incorporation into material compositions may lead to advancements in areas such as polymer science, where it could enhance material characteristics like stability, reactivity, or selectivity.
Used in Catalysis:
In the field of catalysis, 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine may be used as a catalyst or a catalyst precursor. Its unique structure could facilitate novel catalytic pathways, improving the efficiency of chemical reactions and contributing to greener and more sustainable chemical processes.

Upstream product

• 271-63-6 7-Azaindole 
• 1961266-44-3 2,8-difluoro-5-(trifluoromethyl)-5H-dibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate 
• 372-48-5 2-fluoropyridine 
• 892414-45-8 1,1,1-trifluoro-2-(2-fluoropyridin-3-yl)-3-nitropropan-2-ol 
• 932406-33-2 2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethane-1,1-diol 
• 892414-46-9 3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol 

Downstream Products

• 1620574-99-3 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 
• 1150618-36-2 5-bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 
• 1342811-50-0 C₁₅H₈BrF₃N₂O 
• 932406-43-4 benzyl (6-chloro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)(2-fluoro-4-nitrophenyl)acetate 
• 892414-55-0 4-[(6-chloro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]-pyridin-4-yl)oxy]-3,5-difluoroaniline 
• 892414-51-6 6-chloro-4-nitro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine 
• 892414-50-5 6-chloro-4-nitro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Nickel(IV)-Catalyzed C-H Trifluoromethylation of (Hetero)arenes

This Article describes the development of a stable NiIV complex that mediates C(sp2)-H trifluoromethylation reactions. This reactivity is first demonstrated stoichiometrically and then successfully translated to a NiIV-catalyzed C-H trifluoromethylation of electron-rich arene and heteroarene substrates. Both experimental and computational mechanistic studies support a radical chain pathway involving NiIV, NiIII, and NiII intermediates.

TRICYCLIC DLK INHIBITORS AND USES THEREOF

The invention relates to compounds of formula (I) and salts thereof, wherein ring A and R1-R2 have any of the values defined in the specification. The compounds and salts are useful for treating DLK mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as methods of using said compounds, salts, or compositions as DLK inhibitors and for treating neurodegeneration diseases and disorders.

3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS

The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various embodiments thereof. (I) In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6 and R7 have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula (I) as DLK inhibitors and for treating neurodegeneration diseases and disorders.

AZABICYCLO COMPOUND AND SALT THEREOF

It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like.

Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.

Improved synthesis of the selective rho-kinase inhibitor 6-chloro-n4-{3,5-difluoro-4-[(3-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl} pyrimidin-2,4-diamine

A highly potent and selective Rho-kinase inhibitor containing a 7-azaindole moiety has been developed at Bayer Schering Pharma. Herein we disclose details of a significantly improved synthesis of the compound in 8.2% overall yield. Key aspects include cost and safety considerations and the uncommon use of a trifluoromethyl group with controllable reactivity as a masked methyl group.

Synthesis and derivatization of 3-perfluoroalkyl-substituted 7-azaindoles

An expedient large-scale synthesis of 3-perfluoroalkyl-7-azaindoles starting from 2-fluoropyridine is presented. The activation as 6-chloro-4-nitro derivative allows the further derivatization by nucleophilic aromatic substitution in the 4-position. Georg