- HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES
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Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.
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Paragraph 000322
(2016/05/02)
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- NOVEL COMPOUNDS FOR TREATING INFLAMMATORY DISEASES
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The invention relates to novel compounds of formula (1), heteroderivatives thereof, and pharmacologically compatible salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, that are suitable for treating respiratory or gastrointestinal
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Page/Page column 97-98
(2010/11/24)
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- NOVEL AMIDE COMPOUNDS
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A compound of the formula (I):R1-A-X-NHCO-Y-R2 ???whereinR1 is heterocyclic group which may have suitable substituents, or phenyl which may have suitable substituents,R2 is condensed phenyl which may have suitable substituents, phenyl which may have suitable substituents, or thienyl which may have suitable substituents,A is a group of the formula:-(CH2)t-(O)m- or in which R3 and R4 are each hydrogen or linked together to form imino,R5 is hydrogen or lower alkyl,t is 0, 1 or 2,p, m and n are each 0 or 1,X is phenylene which may have suitable substituents, or bivalent heterocyclic group containing nitrogen which may have suitable substituents,Y is bond, lower alkylene, or lower alkenylene, and a salt thereof.
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- Ionization, tautomerism and molecular conformation in aqueous solution of the histamine H2-receptor antagonist mifentidine
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Ionization (pK(a)) and tautomeric (K(t)) constants of mifentidine (DA4577) have been determined in aqueous solution. The predominant molecular species at physiological pH (7.4) is the monocationic form (95.3%) at the formamidine moiety, with the imidazole
- Bazzano,Vavoni,Mondoni,et al.
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