- Palladium-Catalyzed Alkynylation of Morita-Baylis-Hillman Carbonates with (Triisopropylsilyl)acetylene on Water
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Direct alkynylation of Morita-Baylis-Hillman carbonates with (triisopropylsilyl)acetylene catalyzed by a Pd(OAc)2-NHC complex was developed "on water" to give the corresponding 1,4-enynes. The significant effects of water amount in the solvent
- Li, Yangxiong,Liu, Li,Kong, Delong,Wang, Dong,Feng, Weichun,Yue, Tao,Li, Chaojun
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p. 6283 - 6290
(2015/06/30)
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- ANTIPROLIFERATIVE BENZO [B] AZEPIN- 2 - ONES
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Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3 and R4 are described in this application, and methods of using said compounds in the treatment of cancer.
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Page/Page column 49
(2014/02/15)
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- Design, synthesis and identification of novel colchicine-derived immunosuppressant
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Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.
- Chang, Dong-Jo,Yoon, Eun-Young,Lee, Geon-Bong,Kim, Soon-Ok,Kim, Wan-Joo,Kim, Young-Myeong,Jung, Jong-Wha,An, Hongchan,Suh, Young-Ger
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scheme or table
p. 4416 - 4420
(2010/04/05)
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- AMINO ACID COMPOUNDS
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[Problem] To provide novel compounds that are S1P1 receptor agonists and exhibit an immunosuppressive activities by inducing lymphocyte sequestration in secondary lymphoid tissues. In addition, to provide a pharmaceutical agent which comprises the compounds as an effective component, in particular to provide a therapeutic and/or prophylactic agent for an autoimmune disease and the like. [Solving Means] Amino acid compounds that are represented by the following Formula (1) are provided
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Page/Page column 45-46
(2009/12/23)
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- NOVEL MCH RECEPTOR ANTAGONISTS
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The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar1, L1, R1, q, X, R2, R3, R4, and R5 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
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Page/Page column 105-106
(2008/06/13)
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- Recent progress on the iterative construction of 4-substituted-3-hydroxy benzoic acids from unsaturated aldehydes and dimethyl succinate
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An improvement of a known two step cyclization procedure, affording 4-aryl-3-hydroxy benzoic acid derivatives from 3-aryl-2,3-unsaturated aldehydes and dimethyl succinate, is described. The high versatility of the synthetic procedure is shown, as the aryl substituent can be a benzene or naphthalene moiety, or an heteroaromatic ring. It can be applied iteratively to prepare p,p'-oligophenyl derivatives.
- Brenna, Elisabetta,Fuganti, Claudio,Perozzo, Valentina,Serra, Stefano
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p. 15029 - 15040
(2007/10/03)
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