- 5-(1-Piperazinyl)-1H-1,2,4-triazol-3-amines as antihypertensive agents
-
A series of 5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines was synthesized and screened for antihypertensive and diuretic activity in spontaneously hypertensive rats (SHR). One compound, 5-[4-[(3-chlorophenyl)methyl]-1-piperazinyl]-1H-1,2,4-triazol-3-amine (8), was selected to define the mechanism of its antihypertensive activity. Studies in SHR suggest ganglionic blocking activity. Short-lived antihypertensive activity was observed in conscious renal hypertensive dogs.
- Meyer,Tomcufcik,Chan,Haug
-
p. 593 - 597
(2007/10/02)
-
- 2-(substituted-1-piperazinyl)[1,2,4]triazolo[1,5-a]pyrimidines
-
This disclosure describes novel 2-(4-substituted-1-piperazinyl)[1,2,4]triazolo[1,5-a]pyrimidines useful as hypotensive agents.
- -
-
-