89322-56-5

Basic information

• Product Name: 2-broMo-4-ethylthiazole
• Synonyms: 2-broMo-4-ethylthiazole
• CAS NO: 89322-56-5
• Molecular Formula: C₅H₆BrNS
• Molecular Weight: 192.07684
• Mol File: 89322-56-5.mol

Chemical Properties

• Boiling Point: 211.0±9.0 °C(Predicted)
• Appearance: /
• Density: 1.585±0.06 g/cm3(Predicted)
• PKA: 1.42±0.10(Predicted)
• CAS DataBase Reference: 2-broMo-4-ethylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-4-ethylthiazole(89322-56-5)
• EPA Substance Registry System: 2-broMo-4-ethylthiazole(89322-56-5)

Safety Data

• Hazardous Substances Data: 89322-56-5(Hazardous Substances Data)

Usage

Uses

Used in Flavor and Fragrance Industry:
2-Bromo-4-ethylthiazole serves as a flavor and fragrance ingredient, utilized for imparting a meaty note to various products. Its distinct aroma profile makes it a valuable addition in the creation of food products that require a savory or meat-like scent.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-bromo-4-ethylthiazole is employed as an intermediate in the synthesis of different drugs. Its chemical structure plays a crucial role in the development of new medicinal compounds, contributing to the advancement of pharmaceutical formulations.
Safety Precautions:
It is essential to handle 2-bromo-4-ethylthiazole with care due to its potential to cause irritation to the skin, eyes, and respiratory tract. Proper safety measures should be taken to minimize any adverse effects during its use in various applications.

Upstream product

• 34631-53-3 2-amino-4-ethylthiazole 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm

A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 μM. Medicinal chemistry optimization targeted modifications on the left-hand side (LHS), middle section, and right-hand side (RHS) of the scaffold in order to elucidate the structure-activity relationship (SAR). Strong SAR allowed for the iterative and directed assembly of a focus set of 64 analogues, from which compound 60 was identified as the most potent compound, inhibiting the development of the fourth larval (L4) stage with an IC50 of 0.01 μM. In contrast, only 18% inhibition of the mammary epithelial cell line MCF10A viability was observed, even at concentrations as high as 50 μM.