- CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN
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The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.
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Page/Page column 184
(2018/01/17)
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- Fluorescence ratiometric zinc sensors based on controlled energy transfer
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The high-fidelity detection of labile zinc is of central importance for understanding the molecular mechanisms that link zinc homeostasis and human pathophysiology. Fluorescence ratiometric sensors are most suitable for the detection and trafficking of intracellular zinc ions. Here, we report the development of fluorescence ratiometric zinc sensors (HN1 and HN2) based on two-fluorophore platforms. The sensor constructs include blue fluorescent umbelliferone and an energy-accepting chromophore that absorbs the blue fluorescence. Zinc binding was found to promote fluorescence turn-on of the umbelliferone emission by suppression of intramolecular photoinduced electron transfer, thereby facilitating resonance energy transfer to the energy acceptors. The net observables were the fluorescence ratiometric changes, the extent of which depended strongly on the chemical structures of the acceptors. Photophysical investigations, including steady-state and transient photoluminescence spectroscopy, suggested a mechanism for the fluorescent zinc response that involved a combination of the intramolecular electron transfer and the interchromophoric energy transfer. The zinc probes displayed sensing capability that is suitable for the detection of biological zinc ions, with good selectivity, pH tolerance, and appropriate Kd values. Finally, zinc detection was demonstrated by fluorescence ratiometric visualization of exogenously supplied zinc ions in live HeLa cells. The probes enabled the reliable monitoring of zinc equilibration across the cell membrane. The Royal Society of Chemistry 2012.
- Woo, Hana,You, Youngmin,Kim, Taehee,Jhon, Gil-Ja,Nam, Wonwoo
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p. 17100 - 17112
(2012/11/07)
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- Amphiphilic organocatalyst for schotten-baumann-type tosylation of alcohols under organic solvent free condition
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A Tosylation of primary alcohol with tosyl chloride was performed effectively with an W-hexadecylimidazole catalyst in water containing K 2CO3 aggregation of the catalyst carrying a hydrophobic methylene chain worked as a substitute for organic solvent.
- Asano, Keisuke,Matsubara, Seijiro
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supporting information; experimental part
p. 1757 - 1759
(2009/09/06)
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- Synthesis of 1,3-diynes in the purine, pyrimidine, 1,3,5-triazine and acridine series
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A range of conjugated 1,3-diynes, R1C≡CC≡CR2, has been prepared that incorporate the following heteroaromatic units as head groups of the substituents R1 and/or R2: pyrimidinyl, purinyl, 2,4-diamino-1,3,5- triaz
- Edward Lindsell,Murray, Christopher,Preston, Peter N.,Woodman, Thomas A. J.
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p. 1233 - 1245
(2007/10/03)
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- Novel developing agents for (photo) thermographic systems
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A thermographic element comprising in a non-aqueous binder medium a silver salt oxidising agent in reactive association with a compound comprising a plurality of redox colour releasing moieties such that oxidation of each redox colour releasing moiety causes release from said compound of a thermally diffusible dye. The compounds many of which are new incorporate two or more developer moieties into a single molecule to minimise the diffusibility of the compound. Following oxidation, either directly by the silver salt or by means of a cross-oxidising agent, each oxidised developer moiety releases a thermally diffusible dye. The compounds are of sufficient size and molecular weight to slow or prevent diffusion in imaging systems and yet possess several active developer moieties per molecule which is advantageous over known ballasted dye releasers which comprise bulky molecules with only a single developer moiety.
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- New Myocardial Imaging Agents: Stabilization of Radioiodine as a Terminal Vinyl Iodide Moiety on Tellurium Fatty Acids
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To determine the myocardial uptake and retention properties of radioiodinated tellurium fatty acids, we prepared two new tellurium fatty acids in which iodine-125 has been chemically stabilized by attachment as a trans-vinyl iodide (I-CH=CH-R-Te-R'-COOH)
- Knapp, F. F.,Goodman, M. M.,Callahan, A. P.,Ferren, L. A.,Kabalka, G. W.,Sastry, K. A. R.
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p. 1293 - 1300
(2007/10/02)
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