Synthesis of β-blocking oximes. Influence of terminal amine on β-selectivity
Three series of oximinopropanolamine derivatives in which the terminal nitrogen has been substituted by various arylalkyl groups were synthesized. The beta-adrenergic blocking activity of the 21 compounds was determined in vitro on the guinea-pig. The structure-activity relationship is discussed.
Amlaiky,Leclerc,Decker,Schwartz
p. 437 - 439
(2007/10/02)
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