Preparation and Hydrolysis of N-Glucuronides of Pyridine and Piperidine
N-Glucuronides of pyridine and 3-methylpyridine were prepared and the chemical and enzymatic cleavage by base or β-glucuronidase studied respectively.A Km value of 0.08 M was found using E. coli or Helix pomatia enzymes.Catalytic reduction of the N-glucuronide of pyridine caused cleavege of the glucuronide, except when the glucuronide was protected as methyl ester and peracetyl derivative.In this case the N-glucuronide of piperidine was identified by MS and NMR.
Dalgaard, Lars
p. 923 - 928
(2007/10/02)
More Articles about upstream products of 89339-14-0