893638-41-0

Basic information

• Product Name: 5-(4-Pyridyl)isoxazole-3-carboxylic Acid
• Synonyms: 5-(4-Pyridyl)isoxazole-3-carboxylic Acid;5-(4-pyridinyl)-3-Isoxazolecarboxylic acid;5-(Pyridin-4-yl)-1,2-oxazole-3-carboxylic acid
• CAS NO: 893638-41-0
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.15554
• Mol File: 893638-41-0.mol

Chemical Properties

• Boiling Point: 455.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.393±0.06 g/cm3(Predicted)
• PKA: 3?+-.0.10(Predicted)
• CAS DataBase Reference: 5-(4-Pyridyl)isoxazole-3-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Pyridyl)isoxazole-3-carboxylic Acid(893638-41-0)
• EPA Substance Registry System: 5-(4-Pyridyl)isoxazole-3-carboxylic Acid(893638-41-0)

Safety Data

• Hazardous Substances Data: 893638-41-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
5-(4-Pyridyl)isoxazole-3-carboxylic Acid is utilized as a key building block in the creation of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of compounds with specific therapeutic or pesticidal properties, contributing to the advancement of treatments and crop protection strategies.
Used in Anti-Inflammatory and Analgesic Applications:
As an anti-inflammatory and analgesic agent, 5-(4-Pyridyl)isoxazole-3-carboxylic Acid is employed for its potential to alleviate inflammation and pain. Its chemical structure may contribute to modulating biological pathways associated with these conditions, offering a new avenue for the treatment of inflammatory diseases and pain management.
Used in Medicinal Chemistry for Drug Development:
In the field of medicinal chemistry, 5-(4-Pyridyl)isoxazole-3-carboxylic Acid is used as a starting point for the development of new drug candidates. Its versatility in chemical reactions and potential interaction with biological targets make it a promising compound for designing innovative therapeutics aimed at various diseases and disorders.

Upstream product

• 374063-91-9 methyl 2,4-dioxo-4-(pyridin-4-yl)butanoate 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 1620992-47-3 methyl 2-(hydroxyimino)-4-oxo-4-(pyridin-4-yl)butanoate hydrochloride 
• 1692-15-5 4-pyridylboronic acid 
• 854015-41-1 ethyl 5-(pyridin-4-yl)isoxazole-3-carboxylate 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Design, synthesis and biological screening of some pyridinylpyrazole and pyridinylisoxazole derivatives as potential anti-inflammatory, analgesic, antipyretic and antimicrobial agents

A series of substituted pyridinylpyrazole (or isoxazole) derivatives was synthesized and evaluated for their antiinflammatory (AI) activity using formalin-induced paw edema bioassays. The inhibitory activities of cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) were also determined. The analgesic activity of the same compounds was evaluated using rat-tail withdrawal technique. Their antipyretic activity was also evaluated. The results revealed that compounds 4a,b, 6a, 8a, 14c and 15a exhibited significant AI and analgesic activities. Compounds 5a, 6a and 8a displayed good antipyretic activity. Compounds 14c and 15a showed good COX-2 inhibitory activity and weak inhibition of COX- 1. Additionally, the most active compounds were shown to have a large safety margin (ALD50 >300-400 mg/Kg) and minimal ulcerogenic potentialities when administered orally at a dose of 300 mg/Kg. Docking studies for 14c and 15a with COX-2 showed good binding profile. Antimicrobial evaluation proved that most of the compounds exhibited distinctive activity against the gram negative bacteria, P. aeruginosa and E coli.