Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an α-ketothiazole arginine
Using an α-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents.
Deng, Hongfeng,Bannister, Thomas D.,Jin, Lei,Babine, Robert E.,Quinn, Jesse,Nagafuji, Pamela,Celatka, Cassandra A.,Lin, Jian,Lazarova, Tsvetelina I.,Rynkiewicz, Michael J.,Bibbins, Frank,Pandey, Pramod,Gorga, Joan,Meyers, Harold V.,Abdel-Meguid, Sherin S.,Strickler, James E.
p. 3049 - 3054
(2008/09/21)
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