Preparation and Characterization of Porphyrin-Acridine Conjugates as Bifunctional Antitumour Agents
The porphyrin-acridine conjugates (22) and (23) were prepared by condensation of porphyrin (17) with 9-aminoacridine derivative (6) or (15).The conjugate drugs were isolated by size-exclusion chromatography in yields of up to 35percent and further purifie
Potential antitumor agents. 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent
The synthesis and biological activities of representatives of a new class of antitumor agent, the N-[2-(dialkyl-amino)ethyl-9-aminoacridine-4-carboxamides, are reported. Members of this class are stable and very water soluble with high levels of in vitro
Atwell,Cain,Baguley,Finlay,Denny
p. 1481 - 1485
(2007/10/02)
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