89482-03-1

Basic information

• Product Name: zaltoprofen
• Synonyms: Dibenzo[b,f]thiepin-2-acetic acid, 10,11-dihydro-a-methyl-10-oxo-, (R)- (9CI)
• CAS NO: 89482-03-1
• Molecular Formula: MW:
• Molecular Weight: 0
• EINECS: 277-973-5
• Mol File: 89482-03-1.mol

Chemical Properties

• Boiling Point: 500.5°C at 760 mmHg
• Flash Point: 256.5°C
• Appearance: /
• Density: 1.329g/cm³
• Vapor Pressure: 7.72E-11mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: zaltoprofen(CAS DataBase Reference)
• NIST Chemistry Reference: zaltoprofen(89482-03-1)
• EPA Substance Registry System: zaltoprofen(89482-03-1)

Safety Data

• Hazardous Substances Data: 89482-03-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)

Upstream product

• 74711-43-6 zaltoprofen 

Relevant articles and documents

Reshaping the active pocket of esterase Est816 for resolution of economically important racemates

Bacterial esterases are potential biocatalysts for the production of optically pure compounds. However, the substrate promiscuity and chiral selectivity of esterases usually have a negative correlation, which limits their commercial value. Herein, an efficient and versatile esterase (Est816) was identified as a promising catalyst for the hydrolysis of a wide range of economically important substrates with low enantioselectivity. We rationally designed several variants with up to 11-fold increased catalytic efficiency towards ethyl 2-arylpropionates, mostly retaining the initial substrate scope and enantioselectivity. These variants provided a dramatic increase in efficiency for biocatalytic applications. Based on the best variant Est816-M1, several variants with higher or inverted enantioselectivity were designed through careful analysis of the structural information and molecular docking. Two stereoselectively complementary mutants, Est816-M3 and Est816-M4, successfully overcame and even reversed the low enantioselectivity, and several 2-arylpropionic acid derivatives with highEvalues were obtained. Our results offer potential industrial biocatalysts for the preparation of structurally diverse chiral carboxylic acids and further lay the foundation for improving the catalytic efficiency and enantioselectivity of esterases.

OPTICAL ISOMER OF PHENYLPROPIONIC ACID AND ITS MEDICINAL USE

Optical isomers of phenylpropionic acid drugs are a mixture having R-type optical isomer and S-type optical isomer at a ratio of 10:1-1:10 by weight, wherein the ratio of 1:1 is excluded. A use of the optical isomers includes that the R-type optical isomer is used for manufacturing anti-inflammatory and analgesic drugs and the mixture having the R-type optical isomer and the S-type optical isomer at a ratio of 10:1-1:10 by weight, wherein the ratio of 1:1 is excluded, is used for manufacturing anti-inflammatory and analgesic drugs. The therapeutic indexes of anti-inflammatory and analgesic drugs of the present optical isomers are all higher than those of the S-type optical isomers and the racemate.