895525-73-2

Basic information

• Product Name: Tert-Butyl6-bromo-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxylate
• Synonyms: Tert-Butyl6-bromo-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxylate
• CAS NO: 895525-73-2
• Molecular Formula: C₁₇H₂₂BrNO₄
• Molecular Weight: 384.268
• Mol File: 895525-73-2.mol

Chemical Properties

• Boiling Point: 474.441 °C at 760 mmHg
• Flash Point: 240.734 °C
• Appearance: /
• Density: 1.434 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Tert-Butyl6-bromo-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-Butyl6-bromo-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxylate(895525-73-2)
• EPA Substance Registry System: Tert-Butyl6-bromo-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxylate(895525-73-2)

Safety Data

• Hazardous Substances Data: 895525-73-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Tert-Butyl6-bromo-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxylate is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the synthesis of new compounds with potential applications in various industries.
Used in Drug Discovery Research:
In the pharmaceutical industry, Tert-Butyl6-bromo-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxylate is used as a starting material or intermediate in the development of new drugs. Its potential biological activity and diverse functional groups make it an attractive candidate for the design and synthesis of novel therapeutic agents.
Used in Medicinal Chemistry:
Tert-Butyl6-bromo-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxylate is utilized in medicinal chemistry for the study of its structure-activity relationships and the exploration of its potential as a therapeutic agent. Its unique structural features and the presence of various functional groups enable researchers to investigate its interactions with biological targets and evaluate its efficacy in treating specific diseases or conditions.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 2316-64-5 5-bromo-2-hydroxybenzyl alcohol 

Downstream Products

• 895526-12-2 tert-butyl 6-(3-{[(3,4,5-trimethoxyphenyl)acetyl]amino}phenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxylate 
• 895525-98-1 tert-butyl 6-(3-aminophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxylate 
• 895526-00-8 tert-butyl 6-(3-amino-4-methoxyphenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxylate 
• 895526-02-0 3-[1'-(tert-butoxycarbonyl)-4H-spiro[1,3-benzodioxine-2,4'-piperidin]-6-yl]benzoic acid 

Relevant articles and documents

BENZODIOXINONE COMPOUNDS

Provided herein are benzodioxinone compounds of Formula I that are useful as inhibitors of ACC1 and/or ACC2. The benzodioxinone compounds described herein can be used for treating a disease or disorder associated with aberrant ACC1 and/or ACC2 activities, for example, non-alcoholic steatohepatitis (NASH), acne, obesity, diabetes, and cancer. Also provided herein are pharmaceutical compositions comprising the benzodioxinone compound of Formula I, or pharmaceutically acceptable salt thereof.

New compounds

The present invention relates to compounds of Formula (I): wherein R1, A, Y, n and m are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions