89570-85-4Relevant articles and documents
One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis
Akporji, Nnamdi,Braga, Felipe C.,Gabriel, Christopher M.,Landstrom, Evan B.,Lee, Nicholas R.,Lipshutz, Bruce H.
supporting information, (2020/09/02)
An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technology includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes.
Pyridine hydrazone derivative as well as preparation method and application thereof (by machine translation)
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Paragraph 0035-0039, (2020/11/23)
The invention relates to a pyrazine hydrazone derivative represented I, a pharmaceutically acceptable salt thereof, a pharmaceutical composition and application thereof in preparation of an influenza virus neuraminidase inhibitor. Wherein R-substituted pyridyl is selected from the group consisting of 5 - trifluoromethyl -2 - pyridyl, 3 - nitro -2 - pyridyl; Y is selected from the group consisting of: hydroxy, dihydroxyl, 3 - hydroxy -2 - C1 - C2 alkoxy, 3 - hydroxy -4 - C1 - C2 alkoxy, 3 - hydroxy -5 - C1 - C2, 3 -hydroxy -3 - C1 - C2 -6 - C1 - C2 alkoxy 4 -3 4 - hydroxy -2 - C1 - C2-4 - 5 -C1 - C2 dimethyl, Z is 4 - selected from -3: 5 - CH or N. sub. CO. (by machine translation)
FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS
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Page/Page column 106, (2020/12/30)
The present invention discloses a fused heterocyclic compound of formula (I), wherein, R1, Y, Q, A, G,m and E are as defined in the detailed description. The present invention further discloses methods for their preparation and use of the compounds of formula (I) as a pest control agent.
FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS
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Page/Page column 80, (2020/09/19)
The present invention discloses a fused heterocyclic compound of general formula (I), Formula (I) wherein, R1, R3, X, A, m and n are as defined in the detailed description. The present invention further discloses methods for their preparation and use of the fused heterocyclic compounds of general formula (I) as a pest control agent.
Small Molecule Agonists and Antagonists of NR2F6 Activity in Humans
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Paragraph 0069; 0263, (2018/08/20)
The present technology is directed to modulators of nuclear receptor activity, specifically to the modulation of NR2F6 activity and NR2F6 utilizing compounds, and the immune modulation and modulation of cancer stem cell activity through administration of
TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS
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Page/Page column 123, (2014/01/08)
The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.
THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE
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Page/Page column 113, (2010/11/03)
Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS
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Page/Page column 24-25, (2008/12/08)
This invention is directed to compounds of formula (I): wherein m, R1, R2, R3 and R4 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable s
Cycloalkano-indole and -azaindole derivatives
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, (2008/06/13)
Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatheroscle
Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: Synthesis and antiproliferative activity
Easmon,Heinisch,Purstinger,Langer,Osterreicher,Grunicke,Hofmann
, p. 4420 - 4425 (2007/10/03)
A series of N-heteroaryl hydrazones derived from aryl N-heteroaryl or bis-N-heteroaryl methanones was prepared in search for potential novel antitumor agents. The stereochemistry of these compounds was established by means of NMR spectroscopy. Antiproliferative activity was determined in a panel of human tumor cell lines (CCRF-CEM, Burkitt's lymphoma, HeLa, ZR-75- 1, HT-29, and MEXF 276L) in vitro. Generally, the new compounds were found to be more potent (IC50 = 0.011-0.436 μM) than the ribonucleotide reductase inhibitor hydroxyurea (IC50 = 140 μM). Most of the compounds exhibited the highest activity against Burkitt's lymphoma with an IC50 of 0.011-0.035 μM. [14C]Cytidine incorporation into DNA was quantitated for selected hydrazones (Z-A, E-1, Z-3, Z-4, E-5, Z-5, E-13, E-18, Z-19, Z-24, and E-26) as a measure of the inhibition of ribonucleotide reductase in Burkitt's lymphoma cells. The E-configurated compounds were found to inhibit [14C]cytidine incorporation to a greater extent (IC50 = 0.67-5.05 μM) than the Z-isomers (IC50 = 7.20 to > 10 μM). Principal component analysis of the IC50 values obtained for inhibition of cell proliferation revealed that the cell lines tested can be grouped into three main families showing different sensitivities toward the compounds in our series [(i) CCRF-CEM, Burkitt's lymphoma, and Hela; (ii) HT-29; and (iii) MEXF 276 L].
