- Supported palladium oxide nanoparticles in Al-SBA-15 as an efficient and reusable catalyst for the synthesis of pyranopyrazole and benzylpyrazolyl coumarin derivatives via multicomponent reactions
-
An eco-friendly method for diversity-oriented synthesis of substituted dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been achieved via one-pot and multicomponent reaction in the presence of PdO/Al-SBA-15 as an efficient and rec
- Heravi, Majid M.,Malakooti, Reihaneh,Kafshdarzadeh, Kosar,Amiri, Zahra,Zadsirjan, Vahideh,Atashin, Hassan
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p. 203 - 234
(2022/01/19)
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- Magnetization of biochar nanoparticles as a novel support for fabrication of organo nickel as a selective, reusable and magnetic nanocatalyst in organic reactions
-
Catalyst species are an important class of materials in chemistry, industry, medicine and biotechnology. Also, waste recycling is an important process in green chemistry and economic efficiency. Therefore, in order to recycle waste, biochar nanoparticles were prepared from chicken manure. Then, the biochar nanoparticles were magnetized under a green and environmentally friendly method. Finally, the surface of the magnetic biochar nanoparticles was modified and further they were applied as a novel support for fabrication of nickel as a homoselective and reusable catalyst in organic reactions. The structure of this organic-inorganic catalyst has been characterized by N2adsorption-desorption isotherms, and the SEM, EDS, WDX, XRD, TGA, AAS, FT-IR and VSM techniques. This magnetically recyclable catalyst was used in the homoselective synthesis of tetrazole and pyranopyrazole derivatives. This catalyst can be reused several times without significant loss of its catalytic efficiency. The heterogeneity and stability of this nanocatalyst were studied by hot filtration and the AAS technique. Also, the reused catalyst was characterized by the SEM, EDS, AAS and BET techniques.
- Moradi, Parisa,Hajjami, Maryam
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p. 2981 - 2994
(2021/02/26)
-
- An approach to the synthesis and characterization of HMS/Pr-Rh-Zr as efficient catalyst for synthesis of tetrahydrobenzo[b]pyran and 1,4-dihydropyrano[2,3-c]pyrazole derivatives
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The aim of present investigation is the synthesis of mesoporous catalyst based on hexagonal mesoporous silica. HMS support has exceptional properties such as easy synthesis, high surface area, large pore volume and wormhole pores. These distinctive charac
- Abdolahi, Sahar,Hajjami, Maryam,Gholamian, Fatemeh
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p. 1883 - 1904
(2021/02/26)
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- Magnetized melamine-modified polyacrylonitrile (PAN@melamine/Fe3O4) organometallic nanomaterial: Preparation, characterization, and application as a multifunctional catalyst in the synthesis of bioactive dihydropyrano [2,3-c]pyrazole
-
An efficient magnetic polymer-based nanomaterial was prepared in three main steps including synthesis of polyacrylonitrile (PAN), modification of PAN with melamine, and magnetization of the PAN@melamine compound by in situ construction of Fe3O
- Hassanzadeh-Afruzi, Fereshte,Dogari, Haniyeh,Esmailzadeh, Farhad,Maleki, Ali
-
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- Synthesis and characterization of pine-cone derived carbon-based solid acid: A green and recoverable catalyst for the synthesis of pyra-no_pyrazole, amino-benzochromene, amidoalkyl naphthol and thiazoli-dinedione derivatives
-
In this report, SO3H-functionalized Carbon nanoparticles (Pine-SO3H) with high acid density have been synthesized by the thermal treatment of sulfuric acid with Pine-Cone as carbon-based at 180oC in a sealed autoclave in a
- Ghorbani, Fatemeh,Pourmousavi, Seied Ali,Kiyani, Hamzeh
-
-
- Nano cobalt ferrite encapsulated-silica particles bearing melamine as an easily recyclable catalyst for the synthesis of dihydropyrano[2,3-c]pyrazoles under green conditions
-
In this research, it was displayed an efficient method for synthesis of 6-amino-2,4-dihydropyrano[2,3-c] pyrazol-5-carbonitrile derivatives by using CoFe2O4 silica supported bearing melamine as a magnetic nanocatalyst. This nanocompo
- Dadaei, Mahla,Naeimi, Hossein
-
-
- Copper and nickel immobilized on cytosine@MCM-41: as highly efficient, reusable and organic–inorganic hybrid nanocatalysts for the homoselective synthesis of tetrazoles and pyranopyrazoles
-
In this work, a green approach is reported for efficient synthesis of biologically active tetrazole and pyranopyrazole derivatives in the presence of Cu-Cytosine@MCM-41 and Ni-Cytosine@MCM-41 (copper (II) and nickel (II) catalyst on the modified MCM-41 us
- Nikoorazm, Mohsen,Tahmasbi, Bahman,Gholami, Shahab,Moradi, Parisa
-
-
- Catalyst-free green synthesis of dihydropyrano[2,3-c]pyrazole scaffolds assisted by ethylene glycol (E-G) as a reusable and biodegradable solvent medium
-
Abstract: We revealed a catalyst-free, green and rapid one-pot four-component tandem strategy for the preparation of dihydropyrano[2,3-c]pyrazoles – a biologically significant scaffold – via Knoevenagel-Michael cyclocondensation based on green chemistry p
- Mohamadpour, Farzaneh
-
-
- Copper-immobilized ionic liquid as an alternative to organic solvents in the one-pot synthesis of bioactive dihydropyrano[2,3-c]pyrazole derivatives
-
In this study, a novel Cu-immobilized ionic liquid (IL)was designed, characterized, and employed as both promoter and solvent in the synthesis of some dihydropyrano[2,3-c]pyrazoles. The synthesized ionic liquid was characterized by 1H NMR, sup
- Ghafuri, Hossein,Kazemnezhad Leili, Maede,Esmaili Zand, Hamid Reza
-
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- DABA MNPs: A new and efficient magnetic bifunctional nanocatalyst for the green synthesis of biologically active pyrano[2,3-: C] pyrazole and benzylpyrazolyl coumarin derivatives
-
In this work, a new core-shell magnetic silica nanocatalyst functionalized with 3,4-diaminobenzoic acid (Fe3O4@SiO2@PTS-DABA) was successfully prepared and characterized using different spectroscopic methods or techniques including FT-IR, FE-SEM, VSM, XRD
- Karami, Shahriar,Dekamin, Mohammad G.,Valiey, Ehsan,Shakib, Peyman
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p. 13952 - 13961
(2020/09/03)
-
- Novel biocompatible core/shell Fe3O4?NFC?Co(ii) as a new catalyst in a multicomponent reaction: An efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4: H -pyran and pyranopyrazole in aqueous media
-
Today, due to the developing need for inexpensive catalysts, recyclable magnetic nanocatalysts immobilized on polysaccharides possess many advantages over classical heterogeneous catalysts. However, cellulose has been an appealing material in catalysis sc
- Bagherzade, Ghodsieh,Eshghi, Hossein,Kargar, Pouya Ghamari
-
p. 37086 - 37097
(2020/10/27)
-
- Synthesis and characterization of Fe3O4@THAM-SO3H as a highly reusable nanocatalyst and its application for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives
-
In this work, a new, green and beneficial nanomagnetic catalyst was easily fabricated using sulfuric acid as an acidic group on Fe3O4 nanoparticles coated with tris (hydroxymethyl) aminomethane (THAM). The synthesized catalyst was characterized by FT-IR, TGA/DTG, XRD, TEM, EDS, VSM, and SEM analyses. Next, its catalytic activity was studied for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives. This catalyst has advantages such as high catalytic activity, non-toxicity, easy separation from the reaction mixture using an external magnet and reuses for several times without significantly reducing in its catalytic activity.
- Faroughi Niya, Homayoun,Hazeri, Nourallah,Maghsoodlou, Malek Taher
-
-
- Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors
-
The design and synthesis of novel pyrazole based derivatives has been carried out using the ligand based approach like pharmacophore and QSAR modelling of reported pyrazoles from the available literature to investigate the chemical features that are essential for the design of selective and potent COX-2 inhibitors. Both pharmacophore and QSAR models with good statistical parameters were selected for the design of the lead molecule. Also by exploiting the chemical structures of selective and marketed COX-2 inhibitors, celecoxib and SC-558 were used in designing the molecules which are used in the treatment of inflammation and related disorders. The therapeutic action of the Non-Steroidal Anti-inflammatory Agents (NSAIDs) is based primarily on the COX-2 inhibition. With this background we have synthesized some azomethine derivatives of 3-methyl-1-substituted-4-phenyl-6-[{(1E)-phenylmethylene}amino]-1,4-dihydro pyrano[2,3-c]pyrazole-5-carbonitrile 6(a-o) and were characterized by 1HNMR, 13CNMR and Mass spectral techniques. All the synthesized pyrazole derivatives were tested for in vitro membrane stability property in both COX-1 & COX-2 inhibition studies and in vivo anti-inflammatory activity by carrageenan induced rat paw edema model. Among them, compound 6k showed very good activity by in vivo anti-inflammatory activity with 0.8575 mmol/kg as ED50. Similarly compounds 6m, 6o, 6i and 6h exhibited comparable anti-inflammatory activity to standard drugs. Also the active compounds were further screened for ulcerogenic activity and were found be safer with less ulcer index compared to the marketed drugs like aspirin, ibuprofen and celecoxib.
- Murahari, Manikanta,Mahajan, Vivek,Neeladri, Sreenivasulu,Kumar, Maushmi S.,Mayur
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p. 583 - 597
(2019/02/24)
-
- Alpha-Casein: an efficient, green, novel, and eco-friendly catalyst for one-pot multi-component synthesis of bis (pyrazol-5-ols), dihydro-pyrano[2,3-c]pyrazoles and spiropyranopyrazoles in an environmentally benign manner
-
For the first time, alpha-Casein was used as an efficient and eco-friendly catalyst for an effective and facile preparation of dihydropyranopyrazoles and spiropyranopyrazoles. The synthesis of bis (pyrazol-5-ols) derivatives was developed via one-pot, pseudo-five-component condensation, and the target dihydropyrano[2,3-c]pyrazoles and spiropyranopyrazoles were prepared by one-pot four-component reaction. This new method of employing alpha-Casein, which is a green, recyclable, non-toxic and commercially available catalyst, offers advantages such as mild condition, short reaction times, easy work-up, no need for column chromatography, and high yields of the products which make it more economic than other environmentally synthetic protocols.
- Milani, Jalili,Maghsoodlou, Malek Taher,Hazeri, Nourallah,Nassiri, Mahmoud
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p. 1651 - 1664
(2019/04/25)
-
- A convenient route toward one-pot multicomponent synthesis of spirochromenes and pyranopyrazoles accelerated via quinolinic acid
-
In the present work, the catalytic activity of quinolinic acid (QUIN) was studied for the synthesis of spirochromene and pyranopyrazole derivatives from readily available materials. The salient features of these one-pot multicomponent protocols are the clean reaction profile, easy isolation of products, no chromatographic separation techniques, high efficiency, short reaction time, and high yield of products plus using QUIN as a new, inexpensive, commercially available, and efficient organocatalyst.
- Oudi, Maryam,Sanchooli Tazeh, Kazem,Hazeri, Nourallah,Fatahpour, Maryam,Ahmadi, Raheleh
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p. 1721 - 1728
(2019/06/08)
-
- Application of Yttrium Iron Garnet as a Powerful and Recyclable Nanocatalyst for One-Pot Synthesis of Pyrano[2,3-c]pyrazole Derivatives under Solvent-Free Conditions
-
The application of yttrium iron garnet (YIG) superparamagnetic nanoparticles as a new recyclable and highly efficient heterogeneous magnetic catalyst for one-pot synthesis of pyrano[2,3-c]pyrazole derivatives under solvent-free conditions, as well as etherification and esterification reactions are described. The advantages of the proposed method include the lack of organic solvents, clean reaction, rapid removal of the catalyst, short reaction times, excellent yields, and recyclability of the catalyst.
- Sedighinia,Badri,Kiasat
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p. 1755 - 1763
(2020/01/11)
-
- Synthesis and antimicrobial study of 1,4-dihydropyrano[2,3-c]pyrazole derivatives in the presence of amino-functionalized silica-coated cobalt oxide nanostructures as catalyst
-
In this research a series of pyranopyrazoles were efficiently synthesized via the one-pot four-component reactions of ethyl acetoacetate, hydrazinehydrate, aldehydes and malononitrile in the presence of Co3O4@SiO2-tNH
- Shahbazi, Shakiba,Ghasemzadeh, Mohammad Ali,Shakib, Pegah,Zolfaghari, Mohammad Reza,Bahmani, Mahmoud
-
p. 172 - 179
(2019/06/18)
-
- Design and development of a new functionalized cellulose-based magnetic nanocomposite: preparation, characterization, and catalytic application in the synthesis of diverse pyrano[2,3-c]pyrazole derivatives
-
In this work, a facile protocol for the preparation of a new cellulose-based functionalized magnetic nanocomposite catalyst is described. The structure and morphology of the prepared nanomaterial was characterized by scanning electron microscopy, energy-d
- Maleki, Ali,Eskandarpour, Vahid
-
p. 1459 - 1472
(2019/06/10)
-
- Sodium ascorbate as an expedient catalyst for green synthesis of polysubstituted 5-aminopyrazole-4-carbonitriles and 6-amino-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles
-
Sodium ascorbate (SA) was used as a safe catalyst for the synthesis of 5-aminopyrazole-4-carbonitriles from the one-pot three-component cyclocondensation (3-CC) of aldehydes, phenylhydrazine, and malononitrile at 50?°C. This 3-CC proceeds in a mixture of
- Kiyani, Hamzeh,Bamdad, Maryam
-
p. 2761 - 2778
(2018/01/27)
-
- Ce(III) immobilized on aminated poly(vinyl chloride): high-performance synergistic bifunctional acid–base catalyst for one-pot synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles
-
A bifunctional acid–base catalyst of CeIII immobilized on ethylenediamine (EDA)-grafted poly(vinyl chloride) (PVC) has been prepared by a simple approach. First, PVC was treated with EDA to afford aminated poly(vinyl chloride) (PVC–EDA). Therea
- Zhang, Tianzhu,Zhou, Junbin,Chen, Yang,Li, Yiqun
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p. 5329 - 5344
(2018/08/21)
-
- Synergetic effects of naturally sourced metal oxides in organic synthesis: a greener approach for the synthesis of pyrano[2,3-c]pyrazoles and pyrazolyl-4H-chromenes
-
Abstract: A clean and more economic protocol for the synthesis of pyrano[2,3-c]pyrazoles and pyrazolyl-4H-chromenes has been carried out using bael fruit ash (BFA) as a non-conventional natural catalyst in aqueous condition at ambient temperature. The catalyst was obtained from renewable resources by simple thermal treatment to dry rind of Aegle marmelos (Bael) fruit and formation of its active phase was confirmed by AAS, DSC-TGA, XRD, FT-IR, and SEM techniques. The BFA catalyst was found to be a green, highly active, easily biodegradable, and recyclable without loss of activity after the fifth run. The methodology provides an alternative platform to the conventional catalyzed process. Graphical Abstract: [Figure not available: see fulltext.].
- Shinde, Sachin K.,Patil, Megha U.,Damate, Shashikant A.,Patil, Suresh S.
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p. 1775 - 1795
(2017/12/06)
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- Piperidine-Promoted Three-Component Condensation: Synthesis of Chromene Heterocycles and Pyrazolotriazoles
-
Chromenes, the oxygen-containing heterocyclic compounds, have a “special” place in biologically active natural products and in synthetic chemistry and in the fields of medicinal, agrochemical, cosmetic, and pigment industries. In this work, piperidine was used as a base catalyst for the convenient synthesis of 1,4-dihydropyrano[2,3-c]pyrazole, 5,10-dihydro-4H-benzo[g]chromene, and pyrazolo[1,2-a] [1,2,4]triazole derivatives at ambient temperature. This methodology has several advantages including the use of easily accessible and inexpensive catalysts, short reaction times, high yields, convenient work-up, and not needing column chromatography.
- Kangani, Mehrnoush,Hazeri, Nourallah,Yazdani-Elah-Abadi, Afshin,Maghsoodlou, Malek-Taher
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p. 1259 - 1269
(2017/10/18)
-
- Aspirin: an efficient catalyst for synthesis of bis (pyrazol-5-ols), dihydropyrano[2,3-c]pyrazoles and spiropyranopyrazoles in an environmentally benign manner
-
Abstract: This article aimed to present two facile and environmental friendly routes for the rapid assembly of?biologically active compounds including pyrazol core using aspirin as a novel and green catalyst. The synthesis of bis(pyrazol-5-ol) derivatives was developed via one-pot, pseudo-five-component condensation, and the target dihydropyrano[2,3-c]pyrazoles and spiropyranopyrazoles were prepared by one-pot, four-component reaction. These reactions can be performed in tandem from readily available starting materials. The main merits of the present methods are operational simplicity, no need for column chromatography, inexpensive materials, avoidance of harmless and corrosive acid catalysts, short reaction times, good yields of the products, and utilization of aspirin as a non-toxic, cheap, commercially available, and efficient catalyst.
- Fatahpour, Maryam,Noori Sadeh, Fatemeh,Hazeri, Nourallah,Maghsoodlou, Malek Taher,Lashkari, Mojtaba
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p. 1945 - 1956
(2017/08/14)
-
- Method for preparing pyrano[2, 3-c]pyridine derivative through catalysis of basic ionic liquid
-
The invention provides a method for preparing a pyrano[2, 3-c]pyridine derivative through catalysis of a basic ionic liquid, and belongs to the technical field of organic synthesis. The molar ratio of aromatic aldehyde, ethyl acetoacetate or ethyl benzoyl
- -
-
Paragraph 0052; 0053; 0054
(2017/08/22)
-
- Using magnetized water as a solvent for a green, catalyst-free, and efficient protocol for the synthesis of pyrano[2,3-c]pyrazoles and pyrano[4′,3′:5,6]pyrazolo [2,3-d]pyrimidines
-
A facile, eco-friendly, and highly efficient one-pot four-component protocol is demonstrated for the synthesis of the pyrano[2,3-c]pyrazole and pyrano[4′,3′:5,6]pyrazolo [2,3-d]pyrimidine derivatives using magnetized water as a new green solvent. Simplici
- Bakherad, Mohammad,Keivanloo, Ali,Gholizadeh, Mostafa,Doosti, Rahele,Javanmardi, Mohaddese
-
p. 1013 - 1029
(2017/02/10)
-
- One-pot four-component synthesis of 1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles catalyzed by potassium phthalimide
-
The potassium phthalimide (PPI) promoted a domino Knoevenagel-Michael-cyclocondensation of a wide variety of aldehydes, ethyl acetoacetate, malononitrile, and hydrazine derivatives to afford the 1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in high yie
- Kiyani, Hamzeh,Bamdad, Maryam
-
p. 221 - 226
(2017/07/22)
-
- A green and clean pathway: One pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-: C] pyrazoles under catalyst-free and solvent-free conditions
-
A mild, eco-efficient and metal-free synthetic protocol for the production of biologically significant scaffold dihydropyrano[2,3-c]pyrazoles via reaction between ethylacetoacetate (1), hydrazine hydrate (2), aromatic aldehydes (3) and malononitrile (4) a
- Pati Tripathi, Bhartendu,Mishra, Anu,Rai, Pratibha,Kumar Pandey, Yogesh,Srivastava, Madhulika,Yadav, Snehlata,Singh, Jaya,Singh, Jagdamba
-
supporting information
p. 11148 - 11154
(2017/10/05)
-
- Dihydropyrano [2,3-c] pyrazole: Novel in vitro inhibitors of yeast α-glucosidase
-
Inhibition of α-glucosidase enzyme activity is a reliable approach towards controlling post-prandial hyperglycemia associated risk factors. During the current study, a series of dihydropyrano[2,3-C] pyrazoles (1-35) were synthesized and evaluated for thei
- Kashtoh, Hamdy,Muhammad, Munira Taj,Khan, Jalaluddin J.A.,Rasheed, Saima,Khan, Ajmal,Perveen, Shahnaz,Javaid, Kulsoom,Atia-Tul-Wahab,Khan, Khalid Mohammed,Choudhary, M. Iqbal
-
-
- A green and one-pot synthesis of a library of 1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives using thiourea dioxide (TUD) as an efficient and reusable organocatalyst
-
Abstract: The efficacy of thiourea dioxide (TUD) as an efficient, inexpensive, and readily accessible organocatalyst for the synthesis of 1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives via a four-component reaction of ethyl acetoacetate, hyd
- Vekariya, Rajesh H.,Patel, Kinjal D.,Patel, Hitesh D.
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p. 4683 - 4696
(2016/07/06)
-
- Bovine serum albumin: An efficient and green biocatalyst for the one-pot four-component synthesis of pyrano[2,3-c]pyrazoles
-
The use of biocatalysts is attracting an increasing amount of attention in chemical catalysis. Here, we have shown that bovine serum albumin (BSA), a ubiquitous, inexpensive, non-enzymatic transport protein, can serve as an efficient, retrievable catalyst
- Huang, Xingtian,Li, Zhipeng,Wang, Dongyang,Li, Yiqun
-
p. 1461 - 1467
(2016/10/04)
-
- Ionic liquid catalyzed one-pot, three component synthesis of dihydropyrano[2,3-c]pyrazole under green conditions
-
A new series of 6-amino-3-methyl-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives were synthesized, where the three-component reaction of ethyl 3-oxobutanoate, hydrazinehydrate, aromatic aldehyde and malononitrile performed under green
- Yakaiah,Buchappa,Durgaprasad,Ravibabu,Aparna
-
p. 2441 - 2445
(2016/10/12)
-
- An Organobase (TBD)-Anchored Mesoporous Silica Nanoparticle-Catalyzed Green Synthesis of Dihydropyrano[2,3-c]pyrazoles
-
An efficient, mild, and environmental friendly method has been developed for the synthesis of dihydropyrano[2,3-c]pyrazole in ethanolic water over 1,5,7-triazabicyclo-[4,4,0]-dec-1-ene (TBD)-anchored mesoporous silica nanoparticle catalyst. The method inv
- Karmakar, Bikash
-
p. 1117 - 1123
(2016/10/13)
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- Design, synthesis and ex vivo study of the vasorelaxant activity induced by isosteric derivatives of dihydropyridines (NH-O)
-
Background: Hypertension is a complex and multifactorial disorder that is an important cause of morbidity and mortality in all around the world; and the rationalized structural modification of drugs represents an important strategy for to develop new anti
- Rendón-Vallejo, Priscila,Estrada-Soto, Samuel,Vázquez, Miguel A.,Hernández-Borja, Fernando,Villalobos-Molina, Rafael,Ibarra-Barajas, Maximiliano
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p. 353 - 359
(2016/05/24)
-
- Green and highly efficient synthesis of pyranopyrazoles in choline chloride/urea deep eutectic solvent
-
A simple and efficient multicomponent protocol, using ammonium deep eutectic solvent as a dual catalyst and environmentally benign reaction medium, is developed for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives. This operationally simple proto
- Zonouz, Adeleh Moshtaghi,Moghani, Davoud
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p. 220 - 225
(2016/03/09)
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- Four-Component Synthesis of pyrano[2,3-c]pyrazoles Catalyzed by Triphenylphosphine in Aqueous Medium
-
Background: The pyrano[2,3-c]pyrazoles have various biological properties such as antiinflammatory, anti-cancer, antifongical, analgesics and have a potential inhibitor for human ChK1 kinase. For these reasons several synthetic methods are reported. For o
- Khodja, Imène Amine,Fisli, Amina,Lebhour, Oumeima,Boulcina, Raouf,Boumoud, Boudjemaa,Debache, Abdelmadjid
-
-
- Synthesis of Pyranopyrazoles Using Magnetically Recyclable Heterogeneous Iron Oxide-silica Core-shell Nanocatalyst
-
The Fe3O4@SiO2 core-shell nanocatalyst were prepared and efficiently used for four-component coupling reaction of aromatic aldehydes, malononitrile, ethyl acetoacetate and hydrazine hydrate in water/ethanol mixture. Various aromatic aldehydes possessing electron-withdrawing and electron-donating groups in different positions on the ring were successfully transformed to substituted pyranopyrazoles in high yields in short time. The nanocatalyst was easily recovered, and reused five times without significant loss in cata- lytic activity and performance. The structure, size and morphology of the nanosized catalyst were studied by various techniques such as Fourier transform infrared spectroscopy, powder X-ray diffraction, dynamic light scattering and transmission electron microscopy.
- Soleimani, Ebrahim,Jafarzadeh, Mohammad,Norouzi, Parastoo,Dayou, Jedol,Sipaut, Coswald Stephen,Mansa, Rachel Fran,Saei, Parisa
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p. 1155 - 1162
(2016/01/26)
-
- Facile synthesis of pyranopyrazoles and 3,4-dihydropyrimidin-2(1H)-ones by a Ti-grafted polyamidoamine dendritic silica hybrid catalyst via a dual activation route
-
A simple, highly efficient and ecofriendly approach for the preparation of biologically potent pyranopyrazoles and 3,4-dihydropyrimidin-2(1H)-ones are described here. A Ti-grafted polyamidoamine dendritic silica hybrid catalyst was successfully synthesize
- Sinija,Sreekumar
-
p. 101776 - 101788
(2015/12/08)
-
- An efficient organocatalyst for environmentally benign synthesis of pyranopyrazole derivatives in aqueous medium
-
The use of multicomponent reactions as potential synthetic processes, ionic liquids as catalysts and water as reaction medium is a suitable approach that respects, in some extent, the requirements of sustainable chemistry. In this context, we report, here
- Boukezzoula, Faiza,Boumoud, Taoues,Boumoud, Boudjemaa,Debache, Abdelmadjid
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p. 734 - 740
(2016/03/25)
-
- Green procedure for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles using saccharose
-
Saccharose was applied as an efficient and homogeneous catalyst for one-pot, four-component synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives from aromatic aldehydes, malononitrile, ethyl acetoacetate and hydrazine monohydrate under thermal solvent-free conditions. This protocol has a considerable number of advantages including mild condition, high yields, operational simplicity, environmentally benign and simple work-up procedures.
- Kangani, Mehrnoosh,Hazeri, Nourallah,Maghsoodlou, Malek Taher,Khandan-Barani, Khatereh,Kheyrollahi, Maryam,Nezhadshahrokhabadi, Fereshteh
-
-
- Synthesis of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5- carbonitriles by heterogeneous reusable catalysts
-
A new, efficient and environmentally benign protocol for the one-pot, four-component synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles by reaction of hydrazine monohydrate, ethyl acetoacetate, arylaldehydes and malononitrile in the presence of a green catalytic amount of P2O5/SiO 2, H3PO4/Al2O3, cellulose sulfuric acid and starch sulfuric acid is described. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.
- Shaterian, Hamid Reza,Kangani, Mehrnoosh
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p. 1997 - 2005
(2014/05/06)
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- A four-component synthesis of dihydropyrano[2,3-c]pyrazoles in a new water-based worm-like micellar medium
-
Cocamidopropyl betaine (CAPB) as a biodegradable surfactant produces a new worm-like micellar medium for rapid synthesis of dihydropyrano[2,3-c]pyrazoles via a four-component reaction of aldehydes, ethyl acetoacetate, malononitrile, and hydrazine hydrate
- Tamaddon, Fatemeh,Alizadeh, Masoomeh
-
supporting information
p. 3588 - 3591
(2014/06/23)
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- Mild, four-component synthesis of 6-amino-4-aryl-3-methyl-1,4- dihydropyrano[2,3-c]pyrazole-5-carbonitriles catalyzed by titanium dioxide nano-sized particles
-
A convenient and efficient solvent-free procedure is described for preparation of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5- carbonitriles by four-component reaction of hydrazine hydrate, ethyl acetoacetate, aryl aldehyde, and malononitri
- Shaterian, Hamid Reza,Azizi, Kobra
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p. 661 - 667
(2014/02/14)
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- Synthesis of 6-Amino-2,4-dihydropyrano[2,3-c ]pyrazol-5-carbonitriles Catalyzed by Silica-Supported Tetramethylguanidine under Solvent-Free Conditions
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An efficient, high-yielding, and rapid protocol has been developed for the synthesis of diversity-oriented 6-amino-2,4-dihydropyrano[2,3-c]pyrazol-5- carbonitriles derivatives via a four-component, one-pot cyclocondensation reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile using silica-supported tetramethylguanidine as a heterogeneous catalyst for the first time. The protocol proves to be efficient and environmentally benign in terms of very easy workup, good yields, and ease of recovery of catalyst. In addition, the present method is superior in terms of green media, the amount of catalyst, and reaction time.
- Atar, Amol B.,Kim, Jong Tae,Lim, Kwon Taek,Jeong, Yeon Tae
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supporting information
p. 2679 - 2691
(2014/08/18)
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- Ethylenediammonium diformate (EDDF) in PEG600: An efficient ambiphilic novel catalytic system for the one-pot synthesis of 4H-pyrans via Knoevenagel condensation
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A novel ethylenediammonium diformate-polyethylene glycol (EDDF-PEG 600) system was developed as a catalyst for the Knoevenagel condensation and Knoevenagel initiated three-component one-pot synthesis of 4H-pyrans at room temperature with high yields and in short reaction times. Further, the EDDF-PEG600 catalytic system was recycled six times without any appreciable loss in its activity and hence can be termed as a green, environmentally benign catalytic system. A plausible mechanism depicting the ambiphilic nature of EDDF (catalyst) and PEG (promoting medium) acting in synergy has been proposed. The Royal Society of Chemistry.
- Thakur, Anuj,Tripathi, Mohit,Rajesh, U. Chinna,Rawat, Diwan S.
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p. 18142 - 18148
(2013/10/01)
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- Meglumine promoted one-pot, four-component synthesis of pyranopyrazole derivatives
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Meglumine, a bio-based chemical, was demonstrated to be a highly efficient and reusable catalyst for the synthesis of a series of pyranopyrazole derivatives via a one-pot, four-component reaction of carbonyl compound or isatin, hydrazine hydrate, malononi
- Guo, Rui-Yun,An, Zhi-Min,Mo, Li-Ping,Yang, Shu-Tao,Liu, Hong-Xia,Wang, Shu-Xia,Zhang, Zhan-Hui
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p. 9931 - 9938
(2013/11/06)
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- Multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles catalyzed by lipase from Aspergillus niger
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Lipase from Aspergillus niger (ANL) was found to be an extremely effective catalyst for four-component synthesis of dihydropyrano[2,3-c]pyrazoles from a stoichiometric mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde/ketone, and malononitrile in
- Bora, Pranjal P.,Bihani, Manisha,Bez, Ghanashyam
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- Magnetic nanoparticle supported hyperbranched polyglycerol catalysts for synthesis of 4H-benzo[b]pyran
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A magnetic nanoparticle supported hyperbranched polyglycerol catalyst was prepared readily from inexpensive starting materials in aqueous medium that catalyzed the synthesis of 4H-benzo[b]pyran under solvent-free conditions at room temperature. X-ray diff
- Nasseri, Mohammad Ali,Sadeghzadeh, Seyed Mohsen
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p. 1551 - 1558
(2013/10/22)
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