cas 897016-82-9, KX2-391 | Articles data ｜lookchem

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897016-82-9

Articles about 897016-82-9Total 6 be found

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Synthesis method of tebuterin
The invention belongs to the technical field of synthesis of pharmaceutical compounds, and particularly discloses a synthesis method of tebuterin. 2-5 -dibromopyridine is taken as a raw material, and the compound 2 is obtained by reacting with ethyl bromo
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Paragraph 0024-0026; 0030-0031

(2021/09/08)

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)
The discovery of potent, peptide site directed, tyrosine kinase inhibitors has remained an elusive goal. Herein we describe the discovery of two such clinical candidates that inhibit the tyrosine kinase Src. Compound 1 is a phase 3 clinical trial candidat
Smolinski, Michael P.,Bu, Yahao,Clements, James,Gelman, Irwin H.,Hegab, Taher,Cutler, David L.,Fang, Jane W. S.,Fetterly, Gerald,Kwan, Rudolf,Barnett, Allen,Lau, Johnson Y. N.,Hangauer, David G.
p. 4704 - 4719
(2018/06/20)

COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER
The invention relates to compositions and methods for the treatment and prevention of cancer and other cell proliferative disorders.
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(2017/09/05)

PHARMACEUTICAL COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF
The invention relates to a pharmaceutical composition comprising 2-(5-(4-(2- mopholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
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Page/Page column 52-53

(2009/05/28)

COMPOSITION AND METHODS FOR MODULATING A KINASE CASCADE
The invention relates to compositions of N-benzyl-2-(5-(4-(2- morpholinoethoxy)phenyl)pyridin-2-yl)acetamide (KX2-391) and methods for modulating one or more components of a kinase cascade.
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Page/Page column 62

(2008/12/07)

Compositions and methods of treating cell proliferation disorders
The invention relates to compounds and methods for treating cell proliferation disorders.
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Page/Page column 84

(2008/06/13)

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Chemical Properties

Boiling Point: 680.859 °C at 760 mmHg
Flash Point:365.57 °C
Density: 1.169 g/cm³
Solubility:insoluble in H2O; ≥121 mg/mL in DMSO; ≥2.44 mg/mL in EtOH with gentle warming and ultrasonic
PKA: 14.73±0.46(Predicted)
PSA: 67.18000
LogP: 4.09670

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