- Cyclometallated 2-Phenylpyrimidine Derived Platinum Complexes: Synthesis and Photophysical Properties
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A series of five platinum (II) complexes based on 2-phenylpyrimidine ligands have been designed. Pyridine and chloride were used as auxiliary ligands. These complexes exhibit a slightly distorted square-planar geometry. The nature and position of substitu
- Fecková, Michaela,Kahlal, Samia,Roisnel, Thierry,Saillard, Jean-Yves,Boixel, Julien,Hruzd, Mariia,le Poul, Pascal,Gauthier, Sébastien,Robin-le Guen, Fran?oise,Bure?, Filip,Achelle, Sylvain
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p. 1592 - 1600
(2021/04/28)
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- Preparation method of meta-position cyano-aromatic compound
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The invention provides a preparation method of a meta-position cyano-aromatic compound. The meta-position cyano-aromatic compound is obtained by performing reaction on a meta-position formyl-aromaticcompound serving as a raw material and ammonium acetate. The preparation method comprises the following steps: directly adding the meta-position formyl-aromatic compound, the ammonium acetate, iodine,tert-butanol hydrogen peroxide, sodium carbonate and ethanol into a reaction device, stirring and heating to 45 to 55 DEG C, performing reaction for 7 to 9 hours and separating products to obtain themeta-position cyano-aromatic compound. Through the reaction, the meta-position cyano-aromatic compound can be obtained conveniently and rapidly.
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Paragraph 0004; 0017-0018
(2020/02/17)
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- Ruthenium-Catalyzed meta-Selective CAr-H Bond Formylation of Arenes
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The meta-CAr-H bond formylation of arenes has been achieved using CHBr3 as a formyl source in the presence of [Ru(p-cym)(OAc)2] as a catalyst. This method provides efficient access to the preparation of various meta-substituted aromatic compounds, such as alcohols, ethers, amines, nitriles, alkenes, halogens, carboxylic acids, and their derivatives, through transformation of the versatile formyl group. Furthermore, mechanistic studies show that the key active species is a pentagonal ruthenacycle complex.
- Jia, Chunqi,Wu, Nini,Cai, Xiaofeng,Li, Gang,Zhong, Lei,Zou, Lei,Cui, Xiuling
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p. 4536 - 4542
(2020/04/09)
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- Synthesis of nitriles from amines using nanoscale Co3O4-based catalysts via sustainable aerobic oxidation
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The selective oxidation of amines for the benign synthesis of nitriles under mild conditions is described. Key to success for this transformation is the application of reusable cobalt oxide-based nanocatalysts. The resulting nitriles constitute key precursors and central intermediates in organic synthesis.
- Natte, Kishore,Jagadeesh, Rajenahally V.,Sharif, Muhammad,Neumann, Helfried,Beller, Matthias
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supporting information
p. 3356 - 3359
(2016/04/09)
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- "Nanorust"-catalyzed benign oxidation of amines for selective synthesis of nitriles
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Organic nitriles constitute key precursors and central intermediates in organic synthesis. In addition, nitriles represent a versatile motif found in numerous medicinally and biologically important compounds. Generally, these nitriles are synthesized by traditional cyanation procedures using toxic cyanides. Herein, we report the selective and environmentally benign oxidative conversion of primary amines for the synthesis of structurally diverse aromatic, aliphatic and heterocyclic nitriles using a reusable "nanorust" (nanoscale Fe2O3)-based catalysts applying molecular oxygen.
- Jagadeesh, Rajenahally V.,Junge, Henrik,Beller, Matthias
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- Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315
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Substituted pyrimidine inhibitors of the Clk and Dyrk kinases have been developed, exploring structure-activity relationships around four different chemotypes. The most potent compounds have low-nanomolar inhibitory activity against Clk1, Clk2, Clk4, Dyrk
- Coombs, Thomas C.,Tanega, Cordelle,Shen, Min,Wang, Jenna L.,Auld, Douglas S.,Gerritz, Samuel W.,Schoenen, Frank J.,Thomas, Craig J.,Aubé, Jeffrey
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supporting information
p. 3654 - 3661
(2013/07/05)
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